C₂₄H₂₆FN₅O₃S

Base Information

• Chemical Name: C₂₄H₂₆FN₅O₃S
• CAS No.: 1415819-68-9
• Molecular Formula: C₂₄H₂₆FN₅O₃S
• Molecular Weight: 483.567
• Mol file: 1415819-68-9.mol

Synonyms:C₂₄H₂₆FN₅O₃S

Chemical Property of C₂₄H₂₆FN₅O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₆FN₅O₃S

There total 11 articles about C₂₄H₂₆FN₅O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.5%

pyrrolidine (123-75-1) + 4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylic acid (1415820-51-7) → C24H26FN5O3S (1415819-68-9)

Guidance literature:

With di(succinimido) carbonate; triethylamine; In 1,4-dioxane; acetonitrile; at 20 ℃;

Reference yield:

4-fluoro-3-nitrobenzoyl chloride (400-94-2) → C24H26FN5O3S (1415819-68-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: ammonia / toluene; methanol / 0.25 h / 20 °C

2.1: Lawessons reagent / 1,2-dimethoxyethane; tetrahydrofuran / 2 h / 50 °C

2.2: 1 h / 20 °C

3.1: acetic acid / 2 h / Reflux

4.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 72 h / Reflux

5.1: triethylamine / dichloromethane / 1 h / Cooling with ice

6.1: triethylamine / 1,4-dioxane / 2 h / Reflux

7.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 80 °C

8.1: triethylamine; di(succinimido) carbonate / 1,4-dioxane; acetonitrile / 20 °C

With Lawessons reagent; di(succinimido) carbonate; ammonia; water; hydrogen; acetic acid; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; toluene; acetonitrile;

Reference yield:

methyl Pyrrole-2-carboxylate (1193-62-0) → C24H26FN5O3S (1415819-68-9)

Guidance literature:

Multi-step reaction with 7 steps

1: aluminum (III) chloride / dichloromethane / Reflux

2: acetic acid / 2 h / Reflux

3: hydrogen / palladium on activated charcoal / tetrahydrofuran / 72 h / Reflux

4: triethylamine / dichloromethane / 1 h / Cooling with ice

5: triethylamine / 1,4-dioxane / 2 h / Reflux

6: sodium hydroxide; water / 1,4-dioxane / 2 h / 80 °C

7: triethylamine; di(succinimido) carbonate / 1,4-dioxane; acetonitrile / 20 °C

With aluminum (III) chloride; di(succinimido) carbonate; water; hydrogen; acetic acid; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;

upstream raw materials:

pyrrolidine

4-(2-(4-fluoro-3-(2-morpholinoacetamido)phenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylic acid

4-fluoro-3-nitrobenzoyl chloride

methyl Pyrrole-2-carboxylate