6^A,6^C-hexakis(2,3-di-O-methyl)-α-cyclodextrin

Base Information

• Chemical Name: 6^A,6^C-hexakis(2,3-di-O-methyl)-α-cyclodextrin
• CAS No.: 147238-00-4
• Molecular Formula: C₆₆H₁₀₀O₃₂
• Molecular Weight: 1405.5
• Mol file: 147238-00-4.mol

Synonyms:6^A,6^C-hexakis(2,3-di-O-methyl)-α-cyclodextrin

Chemical Property of 6^A,6^C-hexakis(2,3-di-O-methyl)-α-cyclodextrin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 6^A,6^C-hexakis(2,3-di-O-methyl)-α-cyclodextrin

There total 2 articles about 6^A,6^C-hexakis(2,3-di-O-methyl)-α-cyclodextrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

heksakis(2,3-di-O-methyl)-α-cyclodextrin (118663-68-6) → 6A,6C-hexakis(2,3-di-O-methyl)-α-cyclodextrin (147238-00-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 16 percent / pyridine / 3 h / 60 °C

2: 1) NaH / 1) THF, reflux, 30 min, 2) DMF, RT, 24 h

With pyridine; sodium hydride;

DOI:10.1021/jo00061a035

Reference yield:

4-allyloxyphenol (6411-34-3) + 6A,6C-hexakis(2,3-di-O-methyl)-α-cyclodextrin → 6A,6C-hexakis(2,3-di-O-methyl)-α-cyclodextrin (147238-00-4)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) THF, reflux, 30 min, 2) DMF, RT, 24 h;

DOI:10.1021/jo00061a035

Reference yield: 76.0%

6A,6C-hexakis(2,3-di-O-methyl)-α-cyclodextrin (147238-00-4) + methyl iodide (74-88-4) → 6A,6C--6B,6D,6E,6F-tetra-O-methylhexakis(2,3-di-O-methyl)-α-cyclodextrin

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; 1) 0 deg C, 1 h, 2) RT, 24 h;

DOI:10.1021/jo00061a035

upstream raw materials:

4-allyloxyphenol

heksakis(2,3-di-O-methyl)-α-cyclodextrin