(3R,5R)-((R)-3,4-bis (nitrooxy)butyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

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Chemical Name:(3R,5R)-((R)-3,4-bis (nitrooxy)butyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
CAS No.:1353050-28-8
Molecular Formula:C₃₇H₄₁FN₄O₁₁
Molecular Weight:736.751
Hs Code.:

Synonyms:(3R,5R)-((R)-3,4-bis (nitrooxy)butyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

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Chemical Property of (3R,5R)-((R)-3,4-bis (nitrooxy)butyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

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Technology Process of (3R,5R)-((R)-3,4-bis (nitrooxy)butyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

There total 7 articles about (3R,5R)-((R)-3,4-bis (nitrooxy)butyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1353050-07-3
C₄₉H₆₇FN₄O₁₂Si₂

: 1353050-28-8
(3R,5R)-((R)-3,4-bis (nitrooxy)butyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Guidance literature:: With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; at 0 - 20 ℃; for 12h;

Reference yield:

: 134523-03-8
lipitor

: 1353050-28-8
(3R,5R)-((R)-3,4-bis (nitrooxy)butyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 72 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C

3: dimedone / tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / dichloromethane / 3 h

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C

5: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 0 - 20 °C

With 1H-imidazole; dmap; dimedone; triethylamine tris(hydrogen fluoride); 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 915092-85-2
allyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

: 1353050-28-8
(3R,5R)-((R)-3,4-bis (nitrooxy)butyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C

2: dimedone / tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / dichloromethane / 3 h

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C

4: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 0 - 20 °C

With 1H-imidazole; dmap; dimedone; triethylamine tris(hydrogen fluoride); 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;