(2S)-N-(2-(2-(dimethylamino)ethoxy)-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide trifluoroacetate

Base Information

Chemical Name:(2S)-N-(2-(2-(dimethylamino)ethoxy)-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide trifluoroacetate
CAS No.:1240524-69-9
Molecular Formula:C₂HF₃O₂*C₂₉H₃₃N₅O₂S
Molecular Weight:629.703
Hs Code.:

Synonyms:(2S)-N-(2-(2-(dimethylamino)ethoxy)-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide trifluoroacetate

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Chemical Property of (2S)-N-(2-(2-(dimethylamino)ethoxy)-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide trifluoroacetate

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Technology Process of (2S)-N-(2-(2-(dimethylamino)ethoxy)-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide trifluoroacetate

There total 2 articles about (2S)-N-(2-(2-(dimethylamino)ethoxy)-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1240524-47-3
(2S)-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 76-05-1
trifluoroacetic acid

: 1240524-69-9
(2S)-N-(2-(2-(dimethylamino)ethoxy)-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide trifluoroacetate

Guidance literature:: (2S)-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide; (2-chloroethyl)dimethylamine hydrochloride; With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃;

trifluoroacetic acid; In methanol; water; acetonitrile;

Reference yield:

: 1240524-46-2
(2S)-2-amino-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenylpropanamide

: 1240524-69-9
(2S)-N-(2-(2-(dimethylamino)ethoxy)-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane

2.1: caesium carbonate / N,N-dimethyl-formamide / 70 °C

2.2: C₁₈

With sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; In dichloromethane; N,N-dimethyl-formamide;