(2S)-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Base Information

Chemical Name:(2S)-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide
CAS No.:1240524-47-3
Molecular Formula:C₂₅H₂₄N₄O₂S
Molecular Weight:444.557
Hs Code.:

Synonyms:(2S)-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

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Chemical Property of (2S)-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

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Technology Process of (2S)-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

There total 1 articles about (2S)-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 3364-80-5
1,3-thiazole-4-carbaldehyde

: 1240524-46-2
(2S)-2-amino-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenylpropanamide

: 1240524-47-3
(2S)-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Guidance literature:: 1,3-thiazole-4-carbaldehyde; (2S)-2-amino-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenylpropanamide; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield: 66.0%

: 1240524-47-3
(2S)-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

: 96-32-2
bromoacetic acid methyl ester

: 1240524-48-4
methyl 2-(4-(2-methylpyridin-4-yl)-2-((S)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamido)phenoxy)acetate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1240524-47-3
(2S)-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 76-05-1
trifluoroacetic acid

: 1240524-69-9
(2S)-N-(2-(2-(dimethylamino)ethoxy)-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide trifluoroacetate

Guidance literature:: (2S)-N-(2-hydroxy-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide; (2-chloroethyl)dimethylamine hydrochloride; With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃;

trifluoroacetic acid; In methanol; water; acetonitrile;