ethyl 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanate

Base Information

Chemical Name:ethyl 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanate
CAS No.:1256780-26-3
Molecular Formula:C₃₈H₅₈N₄O₅Si
Molecular Weight:678.988
Hs Code.:

Synonyms:ethyl 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanate

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Chemical Property of ethyl 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanate

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Technology Process of ethyl 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanate

There total 6 articles about ethyl 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2969-81-5
Ethyl 4-bromobutyrate

: 1256780-22-9
6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(5-hydroxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-one

: 1256780-26-3
ethyl 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanate

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 15h;

Reference yield:

: 161922-06-1
4-(bromomethyl-2,6-diisopropylphenoxy)(tert-butyl)dimethylsilane

: 1256780-26-3
ethyl 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 18 h / 20 °C

2.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

2.2: 14 h / 70 °C

3.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

3.2: 18 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

5.1: potassium carbonate / acetonitrile / 15 h / 80 °C

With ammonium acetate; hydrogen; trimethylaluminum; sodium hydride; potassium carbonate; acetic acid; palladium 10% on activated carbon; In methanol; n-heptane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1256779-86-8
methyl 2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-oxo heptanate

: 1256780-26-3
ethyl 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

1.2: 14 h / 70 °C

2.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

2.2: 18 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

4.1: potassium carbonate / acetonitrile / 15 h / 80 °C

With ammonium acetate; hydrogen; trimethylaluminum; potassium carbonate; acetic acid; palladium 10% on activated carbon; In methanol; n-heptane; 1,2-dichloro-ethane; toluene; acetonitrile;