4-[2-[4-butyl-5-[4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl]-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanoic acid

Base Information

Chemical Name:4-[2-[4-butyl-5-[4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl]-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanoic acid
CAS No.:1256780-27-4
Molecular Formula:C₃₆H₅₄N₄O₅Si
Molecular Weight:650.934
Hs Code.:

Synonyms:4-[2-[4-butyl-5-[4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl]-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanoic acid

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Chemical Property of 4-[2-[4-butyl-5-[4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl]-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanoic acid

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Technology Process of 4-[2-[4-butyl-5-[4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl]-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanoic acid

There total 7 articles about 4-[2-[4-butyl-5-[4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl]-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256780-26-3
ethyl 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanate

: 1256780-27-4
4-[2-[4-butyl-5-[4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl]-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanoic acid

Guidance literature:: ethyl 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanate; With lithium hydroxide monohydrate; water; In methanol; at 20 ℃; for 12h;

With hydrogenchloride; In methanol; water;

Reference yield:

: 137421-55-7
t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene

: 1256780-27-4
4-[2-[4-butyl-5-[4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl]-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphorus tribromide / toluene / 1 h / 20 °C / cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

3.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

3.2: 14 h / 70 °C

4.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

4.2: 18 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

6.1: potassium carbonate / acetonitrile / 15 h / 80 °C

7.1: water; lithium hydroxide monohydrate / methanol / 12 h / 20 °C

With lithium hydroxide monohydrate; ammonium acetate; water; hydrogen; trimethylaluminum; phosphorus tribromide; sodium hydride; potassium carbonate; acetic acid; palladium 10% on activated carbon; In methanol; n-heptane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1256780-21-8
6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(5-benzyloxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on

: 1256780-27-4
4-[2-[4-butyl-5-[4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl]-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

2: potassium carbonate / acetonitrile / 15 h / 80 °C

3: water; lithium hydroxide monohydrate / methanol / 12 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; palladium 10% on activated carbon; In methanol; acetonitrile;