4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanamide

Base Information

Chemical Name:4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanamide
CAS No.:1256780-28-5
Molecular Formula:C₃₆H₅₅N₅O₄Si
Molecular Weight:649.949
Hs Code.:

Synonyms:4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanamide

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Chemical Property of 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanamide

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Technology Process of 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanamide

There total 8 articles about 4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.8%

: 1256780-27-4
4-[2-[4-butyl-5-[4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl]-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanoic acid

: 1256780-28-5
4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanamide

Guidance literature:: 4-[2-[4-butyl-5-[4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl]-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;

With ammonium hydroxide; In dichloromethane; water; at 20 ℃; for 15h;

Reference yield:

: 137421-55-7
t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene

: 1256780-28-5
4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: phosphorus tribromide / toluene / 1 h / 20 °C / cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

3.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

3.2: 14 h / 70 °C

4.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

4.2: 18 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

6.1: potassium carbonate / acetonitrile / 15 h / 80 °C

7.1: water; lithium hydroxide monohydrate / methanol / 12 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

8.2: 15 h / 20 °C

With lithium hydroxide monohydrate; ammonium acetate; water; hydrogen; trimethylaluminum; phosphorus tribromide; sodium hydride; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; n-heptane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 161922-06-1
4-(bromomethyl-2,6-diisopropylphenoxy)(tert-butyl)dimethylsilane

: 1256780-28-5
4-[2-[4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methyl-6-oxopyrimidin-1(6H)-yl]pyrimidin-5-yloxy]butanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 18 h / 20 °C

2.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

2.2: 14 h / 70 °C

3.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

3.2: 18 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

5.1: potassium carbonate / acetonitrile / 15 h / 80 °C

6.1: water; lithium hydroxide monohydrate / methanol / 12 h / 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

7.2: 15 h / 20 °C

With lithium hydroxide monohydrate; ammonium acetate; water; hydrogen; trimethylaluminum; sodium hydride; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; n-heptane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;