(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Base Information

Chemical Name:(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol
CAS No.:1621255-72-8
Molecular Formula:C₂₆H₂₉BrF₆N₂O₂
Molecular Weight:595.423
Hs Code.:

Synonyms:(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

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Chemical Property of (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

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Technology Process of (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

There total 5 articles about (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.3%

: 1152029-16-7
(1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol

: 1621255-71-7
2-(5-bromo-2-methoxypyridin-2-yl)-5,5-dimethylcyclohex-1-enecarbaldehyde

: 1621255-72-8
(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Guidance literature:: With sodium cyanoborohydride; acetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1621255-70-6
ethyl 2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enecarboxylate

: 1621255-72-8
(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2: Dess-Martin periodane / dichloromethane / 0.5 h / 0 - 20 °C

3: sodium cyanoborohydride; acetic acid / dichloromethane / 2 h / 20 °C

With lithium aluminium tetrahydride; sodium cyanoborohydride; Dess-Martin periodane; acetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1423046-22-3
C₁₇H₂₉BO₄

: 1621255-72-8
(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

3: Dess-Martin periodane / dichloromethane / 0.5 h / 0 - 20 °C

4: sodium cyanoborohydride; acetic acid / dichloromethane / 2 h / 20 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium cyanoborohydride; caesium carbonate; Dess-Martin periodane; acetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1: |Suzuki Coupling;