5-O-benzyl-3-deoxy-3-C-iminopropyl-1,2-O-isopropylidene-3-(2,5-dioxopyrrolidine)-α-D-ribofuranose

Base Information

Chemical Name:5-O-benzyl-3-deoxy-3-C-iminopropyl-1,2-O-isopropylidene-3-(2,5-dioxopyrrolidine)-α-D-ribofuranose
CAS No.:1355966-27-6
Molecular Formula:C₂₂H₂₈N₂O₆
Molecular Weight:416.474
Hs Code.:

Synonyms:5-O-benzyl-3-deoxy-3-C-iminopropyl-1,2-O-isopropylidene-3-(2,5-dioxopyrrolidine)-α-D-ribofuranose

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Chemical Property of 5-O-benzyl-3-deoxy-3-C-iminopropyl-1,2-O-isopropylidene-3-(2,5-dioxopyrrolidine)-α-D-ribofuranose

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Technology Process of 5-O-benzyl-3-deoxy-3-C-iminopropyl-1,2-O-isopropylidene-3-(2,5-dioxopyrrolidine)-α-D-ribofuranose

There total 4 articles about 5-O-benzyl-3-deoxy-3-C-iminopropyl-1,2-O-isopropylidene-3-(2,5-dioxopyrrolidine)-α-D-ribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1355965-96-6
5-O-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-3-(2,5-dioxopyrrolidine)-α-D-ribofuranose

: 925-90-6
ethylmagnesium bromide

: 1355966-27-6
5-O-benzyl-3-deoxy-3-C-iminopropyl-1,2-O-isopropylidene-3-(2,5-dioxopyrrolidine)-α-D-ribofuranose

Guidance literature:: 5-O-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-3-(2,5-dioxopyrrolidine)-α-D-ribofuranose; ethylmagnesium bromide; With methyltriisopropoxytitanium(IV); In tetrahydrofuran; diethyl ether; at 20 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; water;
DOI:10.1016/j.tet.2011.11.067

Reference yield:

: 1355965-95-5
5-O-benzyl-3-carboxypropanamido-3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose

: 1355966-27-6
5-O-benzyl-3-deoxy-3-C-iminopropyl-1,2-O-isopropylidene-3-(2,5-dioxopyrrolidine)-α-D-ribofuranose

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; thionyl chloride / dichloromethane / 6 h / Reflux

2: methyltriisopropoxytitanium(IV) / tetrahydrofuran; diethyl ether / 1 h / 20 °C / Inert atmosphere

With pyridine; thionyl chloride; methyltriisopropoxytitanium(IV); In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.tet.2011.11.067

Reference yield:

: 302582-09-8
3-amino-5-O-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose

: 1355966-27-6
5-O-benzyl-3-deoxy-3-C-iminopropyl-1,2-O-isopropylidene-3-(2,5-dioxopyrrolidine)-α-D-ribofuranose

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 5 h / Reflux

2: pyridine; thionyl chloride / dichloromethane / 6 h / Reflux

3: methyltriisopropoxytitanium(IV) / tetrahydrofuran; diethyl ether / 1 h / 20 °C / Inert atmosphere

With pyridine; thionyl chloride; methyltriisopropoxytitanium(IV); In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1016/j.tet.2011.11.067