Technology Process of (2R,3S)-3-(cyclopropylmethyl)-N-((3S)-9-fluoro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide
There total 18 articles about (2R,3S)-3-(cyclopropylmethyl)-N-((3S)-9-fluoro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1.5 h / 0 °C
1.2: 20 °C
2.1: hydrogen bromide; acetic acid / 1.5 h / 20 °C
3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1.5 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 1.83 h / 20 °C
4.2: 8 - 20 °C
4.3: Lux-Cell4 / 40 °C / 75007.5 Torr / Supercritical conditions; liquid CO2
5.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C
With
oxalyl dichloride; hydrogen bromide; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hexacyanoferrate(II); sodium hydrogencarbonate; sodium hydroxide / N,N-dimethyl-formamide; water / 1.67 h / 110 - 120 °C
2.1: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1.5 h / 0 °C
2.2: 20 °C
3.1: hydrogen bromide; acetic acid / 1.5 h / 20 °C
4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1.5 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 1.83 h / 20 °C
5.2: 8 - 20 °C
5.3: Lux-Cell4 / 40 °C / 75007.5 Torr / Supercritical conditions; liquid CO2
6.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C
With
potassium hexacyanoferrate(II); oxalyl dichloride; hydrogen bromide; sodium hydrogencarbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
