4-(4-methoxyphenyl)-1-[1-(4-methoxyphenyl)-1-methylethyl]-4-methyl-1-[(triisopropylsilyl)ethynyl]pent-2-yn-1-yl methyl carbonate

Base Information

Chemical Name:4-(4-methoxyphenyl)-1-[1-(4-methoxyphenyl)-1-methylethyl]-4-methyl-1-[(triisopropylsilyl)ethynyl]pent-2-yn-1-yl methyl carbonate
CAS No.:949589-14-4
Molecular Formula:C₃₆H₅₀O₅Si
Molecular Weight:590.875
Hs Code.:

Synonyms:4-(4-methoxyphenyl)-1-[1-(4-methoxyphenyl)-1-methylethyl]-4-methyl-1-[(triisopropylsilyl)ethynyl]pent-2-yn-1-yl methyl carbonate

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Chemical Property of 4-(4-methoxyphenyl)-1-[1-(4-methoxyphenyl)-1-methylethyl]-4-methyl-1-[(triisopropylsilyl)ethynyl]pent-2-yn-1-yl methyl carbonate

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Technology Process of 4-(4-methoxyphenyl)-1-[1-(4-methoxyphenyl)-1-methylethyl]-4-methyl-1-[(triisopropylsilyl)ethynyl]pent-2-yn-1-yl methyl carbonate

There total 7 articles about 4-(4-methoxyphenyl)-1-[1-(4-methoxyphenyl)-1-methylethyl]-4-methyl-1-[(triisopropylsilyl)ethynyl]pent-2-yn-1-yl methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 949589-16-6
6-(4-methoxyphenyl)-3-[1-(4-methoxyphenyl)-1-methylethyl]-6-methyl-1-(triisopropylsilyl)hepta-1,4-diyn-3-ol

: 79-22-1
methyl chloroformate

: 949589-14-4
4-(4-methoxyphenyl)-1-[1-(4-methoxyphenyl)-1-methylethyl]-4-methyl-1-[(triisopropylsilyl)ethynyl]pent-2-yn-1-yl methyl carbonate

Guidance literature:: 6-(4-methoxyphenyl)-3-[1-(4-methoxyphenyl)-1-methylethyl]-6-methyl-1-(triisopropylsilyl)hepta-1,4-diyn-3-ol; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h;

methyl chloroformate; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;
DOI:10.1002/ejoc.200700373

Reference yield:

: 5351-07-5
2-(4-methoxy-phenyl)-2-methyl-propionitrile

: 949589-14-4
4-(4-methoxyphenyl)-1-[1-(4-methoxyphenyl)-1-methylethyl]-4-methyl-1-[(triisopropylsilyl)ethynyl]pent-2-yn-1-yl methyl carbonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 91 percent / KOH; water / ethane-1,2-diol / 38 h / Heating

2.1: Et₃N; methanesulfonyl chloride / tetrahydrofuran / 0.17 h / 0 °C

2.2: 80 percent / tetrahydrofuran / 1 h / 0 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

3.2: 82 percent / tetrahydrofuran; hexane / -78 - 20 °C

4.1: nBuLi / tetrahydrofuran / 0.5 h / -78 - 20 °C

4.2: 99 percent / tetrahydrofuran / -78 °C

5.1: NaHDMS / tetrahydrofuran / 0.5 h / -78 - 20 °C

5.2: 93 percent / tetrahydrofuran / -78 - 20 °C

With potassium hydroxide; n-butyllithium; water; sodium hexamethyldisilazane; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; hexane; ethylene glycol;
DOI:10.1002/ejoc.200700373

Reference yield:

: 949589-44-0
N-methoxy-2-(4-methoxyphenyl)-N,2-dimethylpropanamide

: 949589-14-4
4-(4-methoxyphenyl)-1-[1-(4-methoxyphenyl)-1-methylethyl]-4-methyl-1-[(triisopropylsilyl)ethynyl]pent-2-yn-1-yl methyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

1.2: 82 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: nBuLi / tetrahydrofuran / 0.5 h / -78 - 20 °C

2.2: 99 percent / tetrahydrofuran / -78 °C

3.1: NaHDMS / tetrahydrofuran / 0.5 h / -78 - 20 °C

3.2: 93 percent / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; sodium hexamethyldisilazane; In tetrahydrofuran; hexane;
DOI:10.1002/ejoc.200700373