methyl 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzoate

Base Information

• Chemical Name: methyl 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzoate
• CAS No.: 954384-40-8
• Molecular Formula: C₁₉H₁₅Cl₂F₃N₂O₂
• Molecular Weight: 431.242
• Mol file: 954384-40-8.mol

Synonyms:methyl 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzoate

Chemical Property of methyl 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzoate

There total 3 articles about methyl 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3,5-dichlorophenyl)boronic acid (67492-50-6) → methyl 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzoate (954384-40-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; 1,2-dimethoxyethane; water / 3 h / 75 °C

2: N-chloro-succinimide; potassium carbonate / ethyl acetate / 12 h / 20 °C

With potassium hydroxide; N-chloro-succinimide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; ethyl acetate;

Reference yield:

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (864725-22-4) + (E)-1-methyl-4-((2-methylhydrazono)methyl)benzoate (954384-39-5) → methyl 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzoate (954384-40-8)

Guidance literature:

With N-chloro-succinimide; potassium carbonate; In ethyl acetate; at 20 ℃; for 12h;

Reference yield:

methyl 4-formylbenzoate (1571-08-0) → methyl 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzoate (954384-40-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / 1,4-dioxane / 8 h / Heating / reflux

2: N-chloro-succinimide; potassium carbonate / ethyl acetate / 12 h / 20 °C

With N-chloro-succinimide; potassium carbonate; In 1,4-dioxane; ethyl acetate;

upstream raw materials:

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

(E)-1-methyl-4-((2-methylhydrazono)methyl)benzoate

(3,5-dichlorophenyl)boronic acid

methyl 4-formylbenzoate

Downstream raw materials:

4-[5-(3,5-dichlorophenyl)-4,5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzoic acid