1-(4-fluorophenyl)-6-(piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one hydrochloride

Base Information

Chemical Name:1-(4-fluorophenyl)-6-(piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one hydrochloride
CAS No.:1239768-76-3
Molecular Formula:C₂₀H₂₁FN₂O₂*ClH
Molecular Weight:376.858
Hs Code.:

Synonyms:1-(4-fluorophenyl)-6-(piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one hydrochloride

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Chemical Property of 1-(4-fluorophenyl)-6-(piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one hydrochloride

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Technology Process of 1-(4-fluorophenyl)-6-(piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one hydrochloride

There total 1 articles about 1-(4-fluorophenyl)-6-(piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1239768-75-2
tert-butyl 4-(1-(4-fluorophenyl)-2-oxo-1,2,3,4-tetrahydroquinolin-6-yloxy)piperidine-1-carboxylate

: 1239768-76-3
1-(4-fluorophenyl)-6-(piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; ethyl acetate; at 20 ℃;

Reference yield: 52.0%

: 75-30-9
2-iodo-propane

: 1239768-76-3
1-(4-fluorophenyl)-6-(piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one hydrochloride

: 1239768-49-0
1-(4-fluorophenyl)-6-{[1-(propan-2-yl)piperidin-4-yl]oxy}-3,4-dihydroquinolin-2(1H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

Reference yield: 37.0%

: 27374-25-0
[(1-Ethoxycyclopropyl)oxy]trimethylsilane

: 1239768-76-3
1-(4-fluorophenyl)-6-(piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one hydrochloride

: 25895-60-7
sodium cyanoborohydride

: 1239768-52-5
6-[(1-cyclopropylpiperidin-4-yl)oxy]-1-(4-fluorophenyl)-3,4-dihydroquinolin-2(1H)-one

Guidance literature:: [(1-Ethoxycyclopropyl)oxy]trimethylsilane; 1-(4-fluorophenyl)-6-(piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one hydrochloride; With acetic acid; triethylamine; In methanol; at 20 ℃; for 1h; Molecular sieve 3?;

sodium cyanoborohydride; In methanol; at 20 - 95 ℃;