(E)-4-((4-(benzyloxycarbonylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

Base Information

Chemical Name:(E)-4-((4-(benzyloxycarbonylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid
CAS No.:1310809-31-4
Molecular Formula:C₁₆H₂₀N₂O₆
Molecular Weight:336.345
Hs Code.:

Synonyms:(E)-4-((4-(benzyloxycarbonylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

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Chemical Property of (E)-4-((4-(benzyloxycarbonylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

Chemical Property:

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Technology Process of (E)-4-((4-(benzyloxycarbonylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

There total 4 articles about (E)-4-((4-(benzyloxycarbonylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1310809-29-0
(E)-methyl 4-((4-(benzyloxycarbonylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoate

: 1310809-31-4
(E)-4-((4-(benzyloxycarbonylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

Guidance literature:: (E)-methyl 4-((4-(benzyloxycarbonylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoate; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;
DOI:10.1021/ja201597b

Reference yield:

: C₁₄H₂₄N₂O₆

: 1310809-31-4
(E)-4-((4-(benzyloxycarbonylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

2: triethylamine / dichloromethane / 5 h / 0 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 20 °C

With lithium hydroxide monohydrate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja201597b

Reference yield:

: 1310809-22-3
(E)-methyl 4-(benzoyloxy(4-(tert-butoxycarbonylamino)butyl)amino)-4-oxobut-2-enoate

: 1310809-31-4
(E)-4-((4-(benzyloxycarbonylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / methanol / 0.5 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

3: triethylamine / dichloromethane / 5 h / 0 °C

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 20 °C

With lithium hydroxide monohydrate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ja201597b