1-(4,4-difluoro-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

Base Information

Chemical Name:1-(4,4-difluoro-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea
CAS No.:1195173-47-7
Molecular Formula:C₂₅H₂₅F₂N₃O
Molecular Weight:421.49
Hs Code.:

Synonyms:1-(4,4-difluoro-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

Suppliers and Price of 1-(4,4-difluoro-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-(4,4-difluoro-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(4,4-difluoro-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

There total 12 articles about 1-(4,4-difluoro-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1195179-05-5
1-(4-(2-methylpyridin-4-yl)phenyl)-3-(4-oxo-1-phenylcyclohexyl)urea

: 1195173-47-7
1-(4,4-difluoro-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

Guidance literature:: With diethylamino-sulfur trifluoride; at 0 ℃; for 4.5h;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1195173-47-7
1-(4,4-difluoro-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium phosphate / tetrahydrofuran / 0 - 20 °C / pH 6.9

2.1: sodium azide; trifluoroacetic acid / dichloromethane / 2 h / 0 °C

3.1: hydrogen / 10% Pd/C / ethanol / 20 °C

4.1: tetrahydrofuran / 0.25 h / 120 °C / microwave irradiation

4.2: 20 °C

5.1: water; toluene-4-sulfonic acid / acetone / 4 h / 20 °C

6.1: diethylamino-sulfur trifluoride / 4.5 h / 0 °C

With sodium azide; diethylamino-sulfur trifluoride; water; hydrogen; toluene-4-sulfonic acid; sodium phosphate; trifluoroacetic acid; 10% Pd/C; In tetrahydrofuran; ethanol; dichloromethane; acetone;

Reference yield:

: 1195178-97-2
8-azido-8-phenyl-1,4-dioxaspiro[4.5]decane

: 1195173-47-7
1-(4,4-difluoro-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 10% Pd/C / ethanol / 20 °C

2.1: tetrahydrofuran / 0.25 h / 120 °C / microwave irradiation

2.2: 20 °C

3.1: water; toluene-4-sulfonic acid / acetone / 4 h / 20 °C

4.1: diethylamino-sulfur trifluoride / 4.5 h / 0 °C

With diethylamino-sulfur trifluoride; water; hydrogen; toluene-4-sulfonic acid; 10% Pd/C; In tetrahydrofuran; ethanol; acetone;