(4R,5S)-3-<(2R,3R,4E)-3-Hydroxy-2-methyl-5-phenyl-4-pentenoyl>-4-methyl-5-phenyl-2-oxazolidinone

Base Information

• Chemical Name: (4R,5S)-3-<(2R,3R,4E)-3-Hydroxy-2-methyl-5-phenyl-4-pentenoyl>-4-methyl-5-phenyl-2-oxazolidinone
• CAS No.: 138694-16-3
• Molecular Formula: C₂₂H₂₃NO₄
• Molecular Weight: 365.429

Synonyms:(4R,5S)-3-<(2R,3R,4E)-3-Hydroxy-2-methyl-5-phenyl-4-pentenoyl>-4-methyl-5-phenyl-2-oxazolidinone

Chemical Property of (4R,5S)-3-<(2R,3R,4E)-3-Hydroxy-2-methyl-5-phenyl-4-pentenoyl>-4-methyl-5-phenyl-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5S)-3-<(2R,3R,4E)-3-Hydroxy-2-methyl-5-phenyl-4-pentenoyl>-4-methyl-5-phenyl-2-oxazolidinone

There total 1 articles about (4R,5S)-3-<(2R,3R,4E)-3-Hydroxy-2-methyl-5-phenyl-4-pentenoyl>-4-methyl-5-phenyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E)-3-phenylpropenal (14371-10-9) + (4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one (77877-20-4) → (4R,5S)-3-<(2R,3R,4E)-3-Hydroxy-2-methyl-5-phenyl-4-pentenoyl>-4-methyl-5-phenyl-2-oxazolidinone (138694-16-3)

Guidance literature:

(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In dichloromethane; at 0 ℃; for 1h;

(E)-3-phenylpropenal; In dichloromethane; at -78 - 0 ℃; for 2.33333h;

With dihydrogen peroxide; In methanol; dichloromethane; at 10 ℃; Further stages.;

DOI:10.1039/b603433k

Reference yield: 100.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + (4R,5S)-3-<(2R,3R,4E)-3-Hydroxy-2-methyl-5-phenyl-4-pentenoyl>-4-methyl-5-phenyl-2-oxazolidinone (138694-16-3) → (2R,3R,4E)-3-Hydroxy-N-methoxy-N,2-dimethyl-5-phenyl-4-pentenamide (113453-29-5,138694-17-4)

Guidance literature:

With trimethylaluminum; In dichloromethane; at -10 ℃;

DOI:10.1021/jo00030a006

Reference yield: 87.0%

Ν,Ο-dimethylhydroxylamine hydrochloride + (4R,5S)-3-<(2R,3R,4E)-3-Hydroxy-2-methyl-5-phenyl-4-pentenoyl>-4-methyl-5-phenyl-2-oxazolidinone (138694-16-3) → (2R,3R,4E)-3-Hydroxy-N-methoxy-N,2-dimethyl-5-phenyl-4-pentenamide (113453-29-5,138694-17-4)

Guidance literature:

With trimethylaluminum; at -20 - 0 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol300476f

upstream raw materials:

(E)-3-phenylpropenal

(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one

Downstream raw materials:

(2R,3R,4E)-3-Hydroxy-N-methoxy-N,2-dimethyl-5-phenyl-4-pentenamide

(-)-(4R,5S)-3-(E-(2R,3S)-3-methoxy-2-methyl-5-phenyl-pent-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one

(+)-E-(2R,3S)-3-methoxy-2-methyl-5-phenyl-pent-4-enoic acid

(+)-E-(2R,3S)-5-methoxy-4-methyl-3-oxo-7-phenyl-hept-6-enoic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 138694-16-3 (4R,5S)-3-<(2R,3R,4E)-3-Hydroxy-2-methyl-5-phenyl-4-pentenoyl>-4-methyl-5-phenyl-2-oxazolidinone

Send

Send

Metric Ton KG G Pound L ML

Send

Send