(1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)-2-thienyl)-1H-pyrazol-3-yl)acetonitrile

Base Information

Chemical Name:(1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)-2-thienyl)-1H-pyrazol-3-yl)acetonitrile
CAS No.:918321-23-0
Molecular Formula:C₂₂H₁₆ClN₃O₂S₂
Molecular Weight:453.973
Hs Code.:

Synonyms:(1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)-2-thienyl)-1H-pyrazol-3-yl)acetonitrile

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Chemical Property of (1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)-2-thienyl)-1H-pyrazol-3-yl)acetonitrile

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Technology Process of (1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)-2-thienyl)-1H-pyrazol-3-yl)acetonitrile

There total 1 articles about (1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)-2-thienyl)-1H-pyrazol-3-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 918328-01-5
3-bromomethyl-1-(2-chlorophenyl)-5-(5-[3-(methylsulfonyl)phenyl]-thiophen-2-yl)-1H-pyrazole

: 143-33-9,25596-52-5
sodium cyanide

: 918321-23-0
(1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)-2-thienyl)-1H-pyrazol-3-yl)acetonitrile

Guidance literature:: In dimethyl sulfoxide; at 100 ℃; for 5h;

Reference yield: 82.0%

: 918321-23-0
(1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)-2-thienyl)-1H-pyrazol-3-yl)acetonitrile

: methyl (1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)-2-thienyl)-1H-pyrazol-3-yl)acetate

Guidance literature:: (1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)-2-thienyl)-1H-pyrazol-3-yl)acetonitrile; With methanol; sulfuric acid; water; at 90 ℃;

With water; sodium carbonate; In methanol;