(+)-3-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid

Base Information

Chemical Name:(+)-3-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid
CAS No.:1268244-76-3
Molecular Formula:C₂₉H₂₂Cl₃NO₄
Molecular Weight:554.857
Hs Code.:

Synonyms:(+)-3-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid

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Chemical Property of (+)-3-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid

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Technology Process of (+)-3-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid

There total 27 articles about (+)-3-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₂₄Cl₃NO₄

: 1268244-76-3
(+)-3-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 50 ℃;
DOI:10.1016/j.bmcl.2016.05.070

Reference yield:

: 1877-71-0
benzene 1,3-dicarboxylic acid monomethyl ester

: 1268244-76-3
(+)-3-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid

: 1268244-75-2
(-)-3-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: borane-THF / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: phosphorus tribromide / diethyl ether / 2 h

3.1: 4 h / 175 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

4.2: 0 - 20 °C

5.1: triethylamine / dmap / dichloromethane / 1 h / 20 °C

6.1: diethylzinc / dichloromethane; hexane / 0.5 h / -78 °C

6.2: 0.5 h / -30 °C

6.3: 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

9.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 24 h / 20 °C

10.1: CHIRALPAK AD-H / hexane; ethanol; acetic acid / Resolution of racemate

With borane-THF; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; diethylzinc; phosphorus tribromide; sodium hydride; potassium carbonate; triethylamine; dmap; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 108-43-0
3-monochlorophenol

: 1268244-76-3
(+)-3-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid

: 1268244-75-2
(-)-3-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: water; sodium carbonate; calcium hydroxide / 4.33 h / Inert atmosphere; Reflux

2.1: triethylamine / dmap / dichloromethane / 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 0 - 20 °C

4.1: triethylamine / dmap / dichloromethane / 1 h / 20 °C

5.1: diethylzinc / dichloromethane; hexane / 0.5 h / -78 °C

5.2: 0.5 h / -30 °C

5.3: 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 24 h / 20 °C

9.1: CHIRALPAK AD-H / hexane; ethanol; acetic acid / Resolution of racemate

With lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; diethylzinc; sodium hydride; sodium carbonate; potassium carbonate; triethylamine; calcium hydroxide; dmap; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide; mineral oil;