Technology Process of C18H20FNO5S
There total 5 articles about C18H20FNO5S which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
fluoromalonic acid diethyl ester;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 20 ℃;
5-Bromomethyl-2-(4-methoxyphenyl)-thiazole;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
With
acetic acid;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium carbonate / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide; water / 3 h / 100 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C
2.2: 0 °C
3.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0 °C
4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 20 °C
5.2: 2 h / 0 - 20 °C
With
methanol; sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; potassium tert-butylate; sodium carbonate; triphenylphosphine;
palladium diacetate; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C
1.2: 0 °C
2.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0 °C
3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 20 °C
4.2: 2 h / 0 - 20 °C
With
methanol; sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; potassium tert-butylate; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane;
