(S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-methoxycarbonyloxy-6-oxoheptanoic acid methyl ester

Base Information

Chemical Name:(S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-methoxycarbonyloxy-6-oxoheptanoic acid methyl ester
CAS No.:449729-44-6
Molecular Formula:C₂₄H₃₃NO₈S
Molecular Weight:495.594
Hs Code.:

Synonyms:(S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-methoxycarbonyloxy-6-oxoheptanoic acid methyl ester

Suppliers and Price of (S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-methoxycarbonyloxy-6-oxoheptanoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-methoxycarbonyloxy-6-oxoheptanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-methoxycarbonyloxy-6-oxoheptanoic acid methyl ester

There total 13 articles about (S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-methoxycarbonyloxy-6-oxoheptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 541-41-3
chloroformic acid ethyl ester

: 449729-42-4
(S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-hydroxy-6-oxoheptanoic acid methyl ester

: 449729-44-6
(S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-methoxycarbonyloxy-6-oxoheptanoic acid methyl ester

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 0 ℃; for 2.5h;
DOI:10.1021/jo025794+

Reference yield: 100.0%

: 79-22-1
methyl chloroformate

: 449729-42-4
(S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-hydroxy-6-oxoheptanoic acid methyl ester

: 449729-44-6
(S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-methoxycarbonyloxy-6-oxoheptanoic acid methyl ester

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0040-4039(02)00537-3

Reference yield:

: 196930-46-8
(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid

: 449729-44-6
(S)-7-[(2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidin-4-yl]-7-methoxycarbonyloxy-6-oxoheptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 100 percent / SOCl₂ / 17 h / 25 °C

2.1: 100 percent / CaCl₂; NaBH₄ / ethanol / 2 h / -10 - 10 °C

3.1: 88 percent / Na₂CO₃ / tetrahydrofuran; H₂O / 0.5 h / 10 °C

4.1: 95 percent / dimethylsulfoxide; sulfur trioxide pyridine complex; triethylamine / toluene / 2 h / 10 °C

5.1: 100 percent / n-Bu₃P / CH₂Cl₂ / 0.5 h / -10 °C

6.1: Mg / dibutyl ether; toluene / 1.5 h / 40 - 70 °C

6.2: dibutyl ether; toluene / 0.75 h / -30 - -25 °C

6.3: dibutyl ether; toluene / 0.5 h / -30 °C

7.1: 10percent aqueous citric acid / dibutyl ether; toluene

7.2: 37.9 g / K₂CO₃ / dimethylformamide / 10 - 25 °C

8.1: 100 percent / triethylamine; 4-(dimethylamino)pyridine / tetrahydrofuran / 2.5 h / 0 °C

With dmap; sodium tetrahydroborate; thionyl chloride; tributylphosphine; sulfur trioxide pyridine complex; sodium carbonate; magnesium; dimethyl sulfoxide; triethylamine; calcium chloride; In tetrahydrofuran; ethanol; dichloromethane; dibutyl ether; water; toluene;
DOI:10.1021/jo025794+