(E)-6-[4-Hydroxymethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

Base Information

Chemical Name:(E)-6-[4-Hydroxymethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester
CAS No.:1026594-33-1
Molecular Formula:C₂₉H₄₅NO₈
Molecular Weight:535.678
Hs Code.:

(E)-6-[4-Hydroxymethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

Synonyms:(E)-6-[4-Hydroxymethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

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Chemical Property of (E)-6-[4-Hydroxymethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

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Technology Process of (E)-6-[4-Hydroxymethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

There total 6 articles about (E)-6-[4-Hydroxymethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31858-66-9
methyl mycophenolate

: 1026594-33-1
(E)-6-[4-Hydroxymethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: diisopropylethylamine / CH₂Cl₂ / 3 h / Ambient temperature

2: 4 N aq, KOH / methanol / 48 h

3: oxalyl chloride, DMF / ethyl acetate / 1 h

4: DMAP / CH₂Cl₂ / 18 h / Ambient temperature

5: 1.) Me₃Al / 1.) THF, toluene, 30 min, 2.) THF, toluene, a) overnight, b) 50 deg C, 24 h

With dmap; potassium hydroxide; oxalyl dichloride; trimethylaluminum; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm9603633

Reference yield:

: 24280-93-1
mycophenolic acid

: 1026594-33-1
(E)-6-[4-Hydroxymethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / TsOH / 18 h / 25 °C

2: diisopropylethylamine / CH₂Cl₂ / 3 h / Ambient temperature

3: 4 N aq, KOH / methanol / 48 h

4: oxalyl chloride, DMF / ethyl acetate / 1 h

5: DMAP / CH₂Cl₂ / 18 h / Ambient temperature

6: 1.) Me₃Al / 1.) THF, toluene, 30 min, 2.) THF, toluene, a) overnight, b) 50 deg C, 24 h

With dmap; potassium hydroxide; oxalyl dichloride; trimethylaluminum; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm9603633

Reference yield:

: 125198-47-2
methyl (E)-6-<(1,3-dihydro-6-methoxy-4-<(methoxyethoxy)methoxy>-7-methyl-3-oxo-5-isobenzofuranyl)methyl>-4-methyl-4-hexenoate

: 1026594-33-1
(E)-6-[4-Hydroxymethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 4 N aq, KOH / methanol / 48 h

2: oxalyl chloride, DMF / ethyl acetate / 1 h

3: DMAP / CH₂Cl₂ / 18 h / Ambient temperature

4: 1.) Me₃Al / 1.) THF, toluene, 30 min, 2.) THF, toluene, a) overnight, b) 50 deg C, 24 h

With dmap; potassium hydroxide; oxalyl dichloride; trimethylaluminum; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm9603633