Technology Process of 1,7-dimethyl-3-(2-methyl-5-(5-(thiazol-2-yl)-1,2,4-oxadiazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one
There total 17 articles about 1,7-dimethyl-3-(2-methyl-5-(5-(thiazol-2-yl)-1,2,4-oxadiazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,3-thiazole-2-carbonyl chloride; (E)-1-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-2-hydroxyguanidine;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
With
ethanol;
In
tetrahydrofuran;
for 3h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: water; potassium hydroxide / methanol / 14 h / Reflux
2.1: hydrogenchloride / 1,4-dioxane / 14 h / Reflux
2.2: pH > 12
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
5.1: tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation
6.1: potassium acetate / methanol / 0 - 20 °C
7.1: hydroxylamine / ethanol; water / 12 h / 20 °C
8.1: tetrahydrofuran / 0.5 h / 20 °C
8.2: 3 h / Reflux
With
hydrogenchloride; water; hydrogen; hydroxylamine; potassium acetate; potassium carbonate; potassium hydroxide;
tris-(dibenzylideneacetone)dipalladium(0); palladium 10% on activated carbon; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
2.1: tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation
3.1: potassium acetate / methanol / 0 - 20 °C
4.1: hydroxylamine / ethanol; water / 12 h / 20 °C
5.1: tetrahydrofuran / 0.5 h / 20 °C
5.2: 3 h / Reflux
With
hydroxylamine; potassium acetate; potassium carbonate;
tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;