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30216-57-0

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30216-57-0 Usage

Chemical Properties

Light yellow solid

Check Digit Verification of cas no

The CAS Registry Mumber 30216-57-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,2,1 and 6 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 30216-57:
(7*3)+(6*0)+(5*2)+(4*1)+(3*6)+(2*5)+(1*7)=70
70 % 10 = 0
So 30216-57-0 is a valid CAS Registry Number.
InChI:InChI=1/C4H2ClNOS/c5-3(7)4-6-1-2-8-4/h1-2H

30216-57-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,3-Thiazole-2-carbonyl chloride

1.2 Other means of identification

Product number -
Other names thiazolecarboxylic acid chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:30216-57-0 SDS

30216-57-0Relevant articles and documents

Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands

Bian, Jiang,Liu, Yi-Qi,He, Jie,Lin, Xin,Qiu, Chen-Yang,Yu, Wen-Bo,Shen, Yan,Zhu, Ze-Yun,Ye, De-Yong,Wang, Jian,Chu, Yong

, (2021/10/06)

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Early diagnosis is the key to treatment but is still a great challenge in the clinic now. The discovery of alpha-synuclein (α-syn) aggregates ligands has become an attractive s

Discovery of N-(4-sulfamoylphenyl)thioureas as Trypanosoma brucei leucyl-tRNA synthetase inhibitors

Zhang, Fenglong,Du, Jin,Wang, Qing,Hu, Qinghua,Zhang, Jiong,Ding, Dazhong,Zhao, Yaxue,Yang, Fei,Wang, Enduo,Zhou, Huchen

, p. 5310 - 5324 (2013/08/23)

Human African trypanosomiasis (HAT) is one of the most neglected diseases in the tropic regions, which is fatal if not treated in time. There is an urgent need for new therapeutics, especially those in new chemical classes. Leucyl-tRNA synthetase (LeuRS) has been paid much attention as a recently clinically validated antimicrobial target. Our group has previously reported T. brucei LeuRS (TbLeuRS) inhibitors, including benzoxaboroles targeting the editing site and pyrrolinones targeting the synthetic site. Here we report the discovery of N-(4-sulfamoylphenyl)thioureas as a new class of TbLeuRS inhibitors. The R1 and R2 groups, reminiscent of the leucyl and adenyl regions of aa-AMP and aa-AMS, were optimized to result in a significant 13-fold increase of inhibitory activity (compound 19, IC 50 = 13.7 μM). Aided by ligand-protein docking, the 1,3-substitution at the central phenyl ring was predicted and proved to give significantly improved activity (59, IC50 = 1.1 μM). This work provided a new scaffold for the exploration of novel inhibitors against TbLeuRS, which may become potential therapeutics for the treatment of HAT.

Differing Reactivities and Products in the Reaction of Some N-Methylimidazol-2-yl, Oxazol-2-yl and Thiazol-2-ylsilanes and -stannanes with Acid Chlorides

Jutzi, Peter,Gilge, Ullrich

, p. 1011 - 1014 (2007/10/02)

Some new N-methylimidazoles, oxazoles and thiazoles (compounds 7-15) with a keto-function in the 2-position have been synthesized by the reaction of heterocyclic substituted silanes and stannanes with the corresponding acyl chlorides.In cases where the si

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