(R)-2-[((S)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol

Base Information

• Chemical Name: (R)-2-[((S)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol
• CAS No.: 205526-58-5
• Molecular Formula: C₂₆H₃₇NO₆
• Molecular Weight: 459.583
• Mol file: 205526-58-5.mol

Synonyms:(R)-2-[((S)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol

Chemical Property of (R)-2-[((S)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[((S)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol

There total 4 articles about (R)-2-[((S)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.7%

methylmagnesium bromide (75-16-1) + (2R,4R)-2-(3-[1,3]Dioxolan-2-yl-propyl)-4-phenyl-3-(2,4,6-trimethoxy-benzyl)-oxazolidine (205526-52-9) → (R)-2-[((S)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol (205526-58-5)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 ℃; for 72h;

DOI:10.3987/com-97-s32

Reference yield:

2,4,6-trimethoxybenzaldehyde (830-79-5) → (R)-2-[((S)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol (205526-58-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) sodium borohydride / 1.) benzene, reflux, 1 h; 2.) MeOH, r.t., 40 min

2: 100 percent / Na₂SO₄ / CH₂Cl₂ / 48 h / Ambient temperature

3: 89.7 percent / tetrahydrofuran; diethyl ether / 72 h / 0 °C

With sodium tetrahydroborate; sodium sulfate; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.3987/com-97-s32

Reference yield:

D-2-phenylglycinol (56613-80-0) → (R)-2-[((S)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol (205526-58-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) sodium borohydride / 1.) benzene, reflux, 1 h; 2.) MeOH, r.t., 40 min

2: 100 percent / Na₂SO₄ / CH₂Cl₂ / 48 h / Ambient temperature

3: 89.7 percent / tetrahydrofuran; diethyl ether / 72 h / 0 °C

With sodium tetrahydroborate; sodium sulfate; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.3987/com-97-s32

upstream raw materials:

methylmagnesium bromide

(2R,4R)-2-(3-[1,3]Dioxolan-2-yl-propyl)-4-phenyl-3-(2,4,6-trimethoxy-benzyl)-oxazolidine

2,4,6-trimethoxybenzaldehyde

D-2-phenylglycinol

Downstream raw materials:

(2S,1'R)-N-2'-hydroxy-1'-phenylethyl-2-methylpiperidine

(-)-(2'R)-((2S,6S)-2,6-dimethylpiperidin-1-yl)-2'-phenylethanol

(S)-2-methylpiperidine hydrochloride

(3R,5S)-5-methyl-3-phenyl-2,3,5,6,7,8-hexahydro-oxazolo[3,2-a]pyridine