2-chloro-N-(6-(1-methylpiperidin-4-ylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide

Base Information

Chemical Name:2-chloro-N-(6-(1-methylpiperidin-4-ylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide
CAS No.:1143021-22-0
Molecular Formula:C₂₄H₂₃ClN₆O₄S₂
Molecular Weight:559.069
Hs Code.:

Synonyms:2-chloro-N-(6-(1-methylpiperidin-4-ylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide

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Chemical Property of 2-chloro-N-(6-(1-methylpiperidin-4-ylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide

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Technology Process of 2-chloro-N-(6-(1-methylpiperidin-4-ylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide

There total 4 articles about 2-chloro-N-(6-(1-methylpiperidin-4-ylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1143021-24-2
tert-butyl 4-(2-(3-(2-chloro-5-(1H-pyrazol-1-yl)benzoyl)ureido)benzothiazol-6-ylsulfonyl)piperidine-1-carboxylate

: 1143021-22-0
2-chloro-N-(6-(1-methylpiperidin-4-ylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide

Guidance literature:: tert-butyl 4-(2-(3-(2-chloro-5-(1H-pyrazol-1-yl)benzoyl)ureido)benzothiazol-6-ylsulfonyl)piperidine-1-carboxylate; With methanol; acetyl chloride; In methanol; at 50 ℃; for 1h;

formaldehyd; With sodium cyanoborohydride; acetic acid; In methanol; water; for 3h;

Reference yield:

: 88487-25-6
2-chloro-5-fluorobenzamide

: 1143021-22-0
2-chloro-N-(6-(1-methylpiperidin-4-ylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / dimethyl sulfoxide / 18 h / 120 °C / Inert atmosphere

2.1: tetrahydrofuran / 0.08 h / 120 °C / Microwave irradiation

3.1: N,N-dimethyl-formamide / 0.25 h / 80 °C

4.1: acetyl chloride / methanol / 1 h / 50 °C / Cooling with ice

4.2: 3 h

With caesium carbonate; acetyl chloride; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm500610n

Reference yield:

: C₁₁H₇Cl₂N₃O₂

: 1143021-22-0
2-chloro-N-(6-(1-methylpiperidin-4-ylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 0.25 h / 80 °C

2.1: acetyl chloride / methanol / 1 h / 50 °C / Cooling with ice

2.2: 3 h

With acetyl chloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm500610n