tert-butyl 4-(2-(3-(2-chloro-5-(1H-pyrazol-1-yl)benzoyl)ureido)benzothiazol-6-ylsulfonyl)piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-(2-(3-(2-chloro-5-(1H-pyrazol-1-yl)benzoyl)ureido)benzothiazol-6-ylsulfonyl)piperidine-1-carboxylate
CAS No.:1143021-24-2
Molecular Formula:C₂₈H₂₉ClN₆O₆S₂
Molecular Weight:645.16
Hs Code.:

Synonyms:tert-butyl 4-(2-(3-(2-chloro-5-(1H-pyrazol-1-yl)benzoyl)ureido)benzothiazol-6-ylsulfonyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(3-(2-chloro-5-(1H-pyrazol-1-yl)benzoyl)ureido)benzothiazol-6-ylsulfonyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(3-(2-chloro-5-(1H-pyrazol-1-yl)benzoyl)ureido)benzothiazol-6-ylsulfonyl)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-(2-(3-(2-chloro-5-(1H-pyrazol-1-yl)benzoyl)ureido)benzothiazol-6-ylsulfonyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 79-37-8
oxalyl dichloride

: 1143019-70-8
2-chloro-5-(1H-pyrazol-1-yl)benzamide

: 1143021-18-4
tert-butyl 4-(2-aminobenzothiazol-6-ylsulfonyl)piperidine-1-carboxylate

: 1143021-24-2
tert-butyl 4-(2-(3-(2-chloro-5-(1H-pyrazol-1-yl)benzoyl)ureido)benzothiazol-6-ylsulfonyl)piperidine-1-carboxylate

Guidance literature:: oxalyl dichloride; 2-chloro-5-(1H-pyrazol-1-yl)benzamide; In 1,2-dichloro-ethane; at 65 ℃; for 1.5h;

tert-butyl 4-(2-aminobenzothiazol-6-ylsulfonyl)piperidine-1-carboxylate; In N,N-dimethyl-formamide; at 80 ℃; for 0.25h;

Reference yield: 59.0%

: 1143021-18-4
tert-butyl 4-(2-aminobenzothiazol-6-ylsulfonyl)piperidine-1-carboxylate

: C₁₁H₇Cl₂N₃O₂

: 1143021-24-2
tert-butyl 4-(2-(3-(2-chloro-5-(1H-pyrazol-1-yl)benzoyl)ureido)benzothiazol-6-ylsulfonyl)piperidine-1-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 0.25h;
DOI:10.1021/jm500610n

Reference yield:

: 88487-25-6
2-chloro-5-fluorobenzamide

: 1143021-24-2
tert-butyl 4-(2-(3-(2-chloro-5-(1H-pyrazol-1-yl)benzoyl)ureido)benzothiazol-6-ylsulfonyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / dimethyl sulfoxide / 18 h / 120 °C / Inert atmosphere

2: tetrahydrofuran / 0.08 h / 120 °C / Microwave irradiation

3: N,N-dimethyl-formamide / 0.25 h / 80 °C

With caesium carbonate; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm500610n