[1-(4-dimethylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-methyl-carbamic acid tert-butyl ester

Base Information

Chemical Name:[1-(4-dimethylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-methyl-carbamic acid tert-butyl ester
CAS No.:444646-39-3
Molecular Formula:C₂₄H₃₁N₃O₇
Molecular Weight:473.526
Hs Code.:

[1-(4-dimethylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-methyl-carbamic acid <i>tert</i>-butyl ester

Synonyms:[1-(4-dimethylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-methyl-carbamic acid tert-butyl ester

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Chemical Property of [1-(4-dimethylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-methyl-carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of [1-(4-dimethylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-methyl-carbamic acid tert-butyl ester

There total 6 articles about [1-(4-dimethylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-methyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 474295-88-0
[1-(4-dimethylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

: 74-88-4
methyl iodide

: 444646-39-3
[1-(4-dimethylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-methyl-carbamic acid tert-butyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/ol026418e

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 444646-39-3
[1-(4-dimethylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 7.73 g / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 1 h / 20 °C

2: 6.30 g / NaH / dimethylformamide / 18 h / 20 °C

With sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 1: Mitsunobu reaction;
DOI:10.1021/ol026418e

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 444646-39-3
[1-(4-dimethylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / tetrahydrofuran / 5 h / 20 °C

2: 96 percent / potassium carbonate / dimethylformamide / 20 °C

3: 97 percent / LiAlH₄ / tetrahydrofuran / -78 - 0 °C

4: 7.73 g / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 1 h / 20 °C

5: 6.30 g / NaH / dimethylformamide / 18 h / 20 °C

With lithium aluminium tetrahydride; sodium hydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 4: Mitsunobu reaction;
DOI:10.1021/ol026418e