methyl 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)cyclopropanecarboxylate

Base Information

Chemical Name:methyl 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)cyclopropanecarboxylate
CAS No.:1566544-06-6
Molecular Formula:C₁₈H₁₅ClN₂O₂
Molecular Weight:326.782
Hs Code.:

Synonyms:methyl 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)cyclopropanecarboxylate

Suppliers and Price of methyl 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)cyclopropanecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)cyclopropanecarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)cyclopropanecarboxylate

There total 4 articles about methyl 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1780-31-0
2,6-dichloro-5-methylpyrimidine

: 1566543-55-2
methyl 1-(2-ethynylphenyl)cyclopropanecarboxylate

: 1566544-06-6
methyl 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)cyclopropanecarboxylate

Guidance literature:: 2,6-dichloro-5-methylpyrimidine; methyl 1-(2-ethynylphenyl)cyclopropanecarboxylate; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Tetra(tert-butyl)phosphonium-tetrafluoroborat; In 1,4-dioxane; for 0.166667h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

: 124276-87-5
1-(2-bromophenyl)cyclopropanecarboxylic acid

: 1566544-06-6
methyl 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 40 h / 20 °C / Reflux

2.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 16 h / 65 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / dichloromethane / 0.17 h / 0 °C

4.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / 1,4-dioxane / 0.17 h / Inert atmosphere

4.2: 3 h / 80 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1566543-56-3
methyl 1-(2-((trimethylsilyl)ethynyl)phenyl)cyclopropanecarboxylate

: 1566544-06-6
methyl 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / dichloromethane / 0.17 h / 0 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / 1,4-dioxane / 0.17 h / Inert atmosphere

2.2: 3 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; In 1,4-dioxane; dichloromethane;