1-(2-(2-(5-methyl-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Base Information

Chemical Name:1-(2-(2-(5-methyl-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide
CAS No.:1566543-22-3
Molecular Formula:C₂₁H₂₄N₆O
Molecular Weight:376.461
Hs Code.:

Synonyms:1-(2-(2-(5-methyl-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Chemical Property of 1-(2-(2-(5-methyl-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Technology Process of 1-(2-(2-(5-methyl-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

There total 6 articles about 1-(2-(2-(5-methyl-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1566544-07-7
methyl 1-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxylate

: 69843-13-6
1-methyl-4-aminopyrazole

: 1566543-22-3
1-(2-(2-(5-methyl-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: methyl 1-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxylate; 1-methyl-4-aminopyrazole; With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 - 35 ℃; for 120h;

With ammonium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 - 35 ℃; for 48h;

Reference yield:

: 1566544-06-6
methyl 1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)cyclopropanecarboxylate

: 1566543-22-3
1-(2-(2-(5-methyl-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; platinum(IV) oxide / N,N-dimethyl-formamide; methanol / 16 h / 20 °C

2.1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

2.2: 120 h / 20 - 35 °C

2.3: 48 h / 20 - 35 °C

With platinum(IV) oxide; hydrogen; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 124276-87-5
1-(2-bromophenyl)cyclopropanecarboxylic acid

: 1566543-22-3
1-(2-(2-(5-methyl-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / water / 40 h / 20 °C / Reflux

2.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 16 h / 65 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / dichloromethane / 0.17 h / 0 °C

4.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / 1,4-dioxane / 0.17 h / Inert atmosphere

4.2: 3 h / 80 °C / Inert atmosphere

5.1: hydrogen; platinum(IV) oxide / N,N-dimethyl-formamide; methanol / 16 h / 20 °C

6.1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

6.2: 120 h / 20 - 35 °C

6.3: 48 h / 20 - 35 °C

With hydrogenchloride; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen; palladium diacetate; caesium carbonate; Tetra(tert-butyl)phosphonium-tetrafluoroborat; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;