tert-butyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate

Base Information

Chemical Name:tert-butyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate
CAS No.:1247847-52-4
Molecular Formula:C₁₉H₂₇F₂O₅P
Molecular Weight:404.391
Hs Code.:

Synonyms:tert-butyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate

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Chemical Property of tert-butyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate

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Technology Process of tert-butyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate

There total 3 articles about tert-butyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 1247847-51-3
tert-butyl (E)-3-(4-iodophenyl)but-2-enoate

: 1247847-52-4
tert-butyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate

Guidance literature:: diethyl (bromodifluoromethyl)phosphonate; With cadmium; In N,N-dimethyl-formamide; for 8h; Inert atmosphere;

tert-butyl (E)-3-(4-iodophenyl)but-2-enoate; With copper(l) chloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield: 68.0%

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 1247847-51-3
tert-butyl (E)-3-(4-iodophenyl)but-2-enoate

: 1247847-52-4
tert-butyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate

: C₁₉H₂₇F₂O₅P

Guidance literature:: diethyl (bromodifluoromethyl)phosphonate; With cadmium; In N,N-dimethyl-formamide; for 8h; Inert atmosphere;

tert-butyl (E)-3-(4-iodophenyl)but-2-enoate; With copper(l) chloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jm2000882

Reference yield:

: 13329-40-3
4-Iodoacetophenone

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 1247847-52-4
tert-butyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate

: C₁₉H₂₇F₂O₅P

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium tert-butoxide / tetrahydrofuran; hexane; tert-butyl alcohol / 1 h

2.1: cadmium / N,N-dimethyl-formamide / 8 h / Inert atmosphere

2.2: 24 h / 20 °C

With cadmium; lithium tert-butoxide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm2000882