1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid tris(hydroxymethyl)aminomethane salt

Base Information

Chemical Name:1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid tris(hydroxymethyl)aminomethane salt
CAS No.:1203588-12-8
Molecular Formula:C₄H₁₁NO₃*C₂₂H₂₂F₃NO₄S
Molecular Weight:574.618
Hs Code.:

Synonyms:1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid tris(hydroxymethyl)aminomethane salt

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Chemical Property of 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid tris(hydroxymethyl)aminomethane salt

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Technology Process of 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid tris(hydroxymethyl)aminomethane salt

There total 5 articles about 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid tris(hydroxymethyl)aminomethane salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1203588-09-3
1-[[3-(1-Methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 1203588-12-8
1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid tris(hydroxymethyl)aminomethane salt

Guidance literature:: In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 927963-32-4
methyl 6-[2-amino-5-(trifluoromethyl)phenyl]hex-5-ynoate

: 1203588-12-8
1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid tris(hydroxymethyl)aminomethane salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 15 h / 20 °C

2.1: copper(II) acetate monohydrate / 1,2-dichloro-ethane / 15 h / Inert atmosphere; Reflux

3.1: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

3.2: 0 °C

4.1: water; tetrahydrofuran / 20 °C

With pyridine; water; copper(II) acetate monohydrate; lithium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane;

Reference yield:

: 71530-58-0
m-cumenesulfonyl chloride

: 1203588-12-8
1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid tris(hydroxymethyl)aminomethane salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 15 h / 20 °C

2.1: copper(II) acetate monohydrate / 1,2-dichloro-ethane / 15 h / Inert atmosphere; Reflux

3.1: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

3.2: 0 °C

4.1: water; tetrahydrofuran / 20 °C

With pyridine; water; copper(II) acetate monohydrate; lithium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane;