Piperazine, 2-methyl-1-(1-oxopropyl)- (9CI)

Base Information

• Chemical Name: Piperazine, 2-methyl-1-(1-oxopropyl)- (9CI)
• CAS No.: 314729-13-0
• Molecular Formula: C8H16 N2 O
• Molecular Weight: 156.22544
• Mol file: 314729-13-0.mol

Synonyms:Piperazine,2-methyl-1-(1-oxopropyl)- (9CI); 2-Methyl-1-propionylpiperazine

Chemical Property of Piperazine, 2-methyl-1-(1-oxopropyl)- (9CI)

Chemical Property:

• Boiling Point: 277.1±33.0 °C(Predicted)
• PKA: 8.47±0.40(Predicted)
• PSA: 32.34000
• Density: 0.968±0.06 g/cm3(Predicted)
• LogP: 0.48340

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperazine, 2-methyl-1-(1-oxopropyl)- (9CI)

There total 3 articles about Piperazine, 2-methyl-1-(1-oxopropyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

4-benzyl-2-methyl-1-propionylpiperazine (314729-19-6) → 2-methyl-1-propionylpiperazine (314729-13-0)

Guidance literature:

With hydrogen; 10percent Pd/C; In ethanol; for 12h; under 2430.66 Torr;

DOI:10.1021/jm000972h

Reference yield:

(RS)-2-methylpiperazine (109-07-9) → 2-methyl-1-propionylpiperazine (314729-13-0)

Guidance literature:

Multi-step reaction with 3 steps

2: 95 percent / CH₂Cl₂ / 50 °C

3: 38 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 2430.66 Torr

With hydrogen; 10percent Pd/C; In ethanol; dichloromethane;

DOI:10.1021/jm000972h

Reference yield:

3-methyl-1-(phenylmethyl)piperazine (3138-90-7) → 2-methyl-1-propionylpiperazine (314729-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / CH₂Cl₂ / 50 °C

2: 38 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 2430.66 Torr

With hydrogen; 10percent Pd/C; In ethanol; dichloromethane;

DOI:10.1021/jm000972h

upstream raw materials:

4-benzyl-2-methyl-1-propionylpiperazine

(RS)-2-methylpiperazine

3-methyl-1-(phenylmethyl)piperazine

Refernces