ethyl 2-(2-methoxy-4-(prop-1-enyl)phenoxy)acetate

Base Information

• Chemical Name: ethyl 2-(2-methoxy-4-(prop-1-enyl)phenoxy)acetate
• CAS No.: 632290-89-2
• Molecular Formula: C₁₄H₁₈O₄
• Molecular Weight: 250.295
• Mol file: 632290-89-2.mol

Synonyms:ethyl 2-(2-methoxy-4-(prop-1-enyl)phenoxy)acetate

Chemical Property of ethyl 2-(2-methoxy-4-(prop-1-enyl)phenoxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(2-methoxy-4-(prop-1-enyl)phenoxy)acetate

There total 1 articles about ethyl 2-(2-methoxy-4-(prop-1-enyl)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(4-formyl-2-methoxyphenoxy)acetate (51264-70-1) + ethylenetriphenylphosphorane (1754-88-7) → ethyl 2-(2-methoxy-4-(prop-1-enyl)phenoxy)acetate (632290-89-2)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; for 4h; Reflux; Inert atmosphere;

DOI:10.1055/s-0031-1290678

Reference yield: 97.0%

ethyl 2-(2-methoxy-4-(prop-1-enyl)phenoxy)acetate (632290-89-2) → C14H18O4 (1395081-54-5)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); In dichloromethane; at 20 ℃; for 24h; optical yield given as %de; Inert atmosphere;

DOI:10.1055/s-0031-1290678

Reference yield:

ethyl 2-(2-methoxy-4-(prop-1-enyl)phenoxy)acetate (632290-89-2) → (1R,2R)-2-(2-methoxy-4-((E)-prop-1-enyl)phenoxy)-1-(3,4,5-trimethoxyphenyl)propane-1,3-diol (1395081-64-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dichloro bis(acetonitrile) palladium(II) / dichloromethane / 24 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol; dichloromethane / 3 h / 20 °C / Inert atmosphere

2.2: 0 °C / pH 2 - 3 / Inert atmosphere

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; toluene / 0.33 h / 0 °C / Inert atmosphere

4.2: 3.33 h / -78 - 20 °C / Inert atmosphere

5.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

5.2: 0.5 h / 20 °C / Inert atmosphere

5.3: 4.75 h / -78 - 0 °C / Inert atmosphere

6.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; 5.1: Aldol condensation / 5.2: Aldol condensation / 5.3: Aldol condensation;

DOI:10.1055/s-0031-1290678

upstream raw materials:

ethyl 2-(4-formyl-2-methoxyphenoxy)acetate

ethylenetriphenylphosphorane

Downstream raw materials:

(S,E)-4-isopropyl-3-(2-(2-methoxy-4-(prop-1-enyl)phenoxy)acetyl)-5,5-diphenyloxazolidin-2-one

(S)-3-((2S,3R)-3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxy-4-((E)-prop-1-enyl)phenoxy)propanoyl)-4-isopropyl-5,5-diphenyloxazolidin-2-one

(S)-3-((2S,3R)-3-hydroxy-2-(2-methoxy-4-((E)-prop-1-enyl)phenoxy)-3-(3,4,5-trimethoxyphenyl)propanoyl)-4-isopropyl-5,5-diphenyloxazolidin-2-one

(1R,2R)-1-(3,4-dimethoxyphenyl)-2-(2-methoxy-4-((E)-prop-1-enyl)phenoxy)propane-1,3-diol