4-(3-Chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid

Base Information

• Chemical Name: 4-(3-Chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid
• CAS No.: 314000-19-6
• Molecular Formula: C12H11 Cl N2 O3
• Molecular Weight: 266.68
• Hs Code.: 2933599090
• Mol file: 314000-19-6.mol

Synonyms:4-(3-Chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid;4-(3-Chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Chemical Property of 4-(3-Chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid

Chemical Property:

• PSA: 81.92000
• LogP: 2.02130
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

4-(3-Chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-Chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid

There total 2 articles about 4-(3-Chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl-4-(3-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate → 4-(3-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (314000-19-6)

Guidance literature:

carbon palladium; In ethyl acetate;

Reference yield:

2-acetoacetic acid (541-50-4) + m-Chlorobenzaldehyde (587-04-2) + urea (57-13-6) → 4-(3-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (314000-19-6)

Guidance literature:

In ethanol; Acidic conditions; Reflux;

DOI:10.1111/cbdd.12373

Reference yield:

3-(1H-imidazol-1-yl)propan-1-amine (5036-48-6) + 4-(3-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (314000-19-6) → 4-(3-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (3-imidazole-1-yl-propyl)amide

Guidance literature:

In N,N-dimethyl-formamide;

upstream raw materials:

2-acetoacetic acid

m-Chlorobenzaldehyde

urea

Refernces

• 1、 -. "Dihydropyrimidine compounds and compositions containing the same". . . Retrieved 2008/06/13.