3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Base Information

Chemical Name:3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
CAS No.:1221349-39-8
Molecular Formula:C₂₂H₂₁F₂N₃O₂
Molecular Weight:397.424
Hs Code.:

Synonyms:3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Suppliers and Price of 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

There total 7 articles about 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259026-33-9
1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid chloride

: C₁₃H₁₂F₂N₂O

: 1221349-39-8
3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: 1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid chloride; C₁₃H₁₂F₂N₂O; With triethylamine; In dichloromethane; at 20 ℃; for 2h;

With camphor-10-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 3h;
DOI:10.1021/jm101075v

Reference yield:

: 175278-33-8
1-bromo-2-(dilfluoromethoxy)benzene

: 1221349-39-8
3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane; water / 18 h / 90 °C / Inert atmosphere

2.1: hydrogenchloride; iron / ethanol; water / 4 h / 80 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

3.2: 3 h / 100 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iron; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1.1: Suzuki coupling;
DOI:10.1021/jm101075v

Reference yield:

: 1015770-74-7
1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid ethyl ester

: 1221349-39-8
3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydrochloride monohydrate; water / methanol / 16 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

3.2: 3 h / 100 °C

With oxalyl dichloride; lithium hydrochloride monohydrate; water; triethylamine; N,N-dimethyl-formamide; In methanol; dichloromethane;
DOI:10.1021/jm101075v