3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Base Information

Chemical Name:3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride
CAS No.:1259026-79-3
Molecular Formula:C₂₂H₂₁F₂N₃O₂*ClH
Molecular Weight:433.885
Hs Code.:

Synonyms:3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

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Chemical Property of 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

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Technology Process of 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

There total 8 articles about 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1221349-39-8
3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

: 1259026-79-3
3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; ethyl acetate;
DOI:10.1021/jm101075v

Reference yield:

: 175278-33-8
1-bromo-2-(dilfluoromethoxy)benzene

: 1259026-79-3
3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane; water / 18 h / 90 °C / Inert atmosphere

2.1: hydrogenchloride; iron / ethanol; water / 4 h / 80 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

3.2: 3 h / 100 °C

4.1: hydrogenchloride / diethyl ether; ethyl acetate

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iron; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; 1.1: Suzuki coupling;
DOI:10.1021/jm101075v

Reference yield:

: 1015770-74-7
1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid ethyl ester

: 1259026-79-3
3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydrochloride monohydrate; water / methanol / 16 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

3.2: 3 h / 100 °C

4.1: hydrogenchloride / diethyl ether; ethyl acetate

With hydrogenchloride; oxalyl dichloride; lithium hydrochloride monohydrate; water; triethylamine; N,N-dimethyl-formamide; In methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm101075v