2-Chloro-n,6-dimethyl-5-nitropyrimidin-4-amine

Base Information

Chemical Name:2-Chloro-n,6-dimethyl-5-nitropyrimidin-4-amine
CAS No.:5177-14-0
Molecular Formula:C₆H₇ClN₄O₂
Molecular Weight:202.6
Hs Code.:
NSC Number:134520
DSSTox Substance ID:DTXSID10300063
Wikidata:Q82042847
Mol file:5177-14-0.mol

Synonyms:2-chloro-n,6-dimethyl-5-nitropyrimidin-4-amine;5177-14-0;NSC134520;DTXSID10300063;STL227844;AKOS000320463;NSC-134520

Suppliers and Price of 2-Chloro-n,6-dimethyl-5-nitropyrimidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 2-Chloro-n,6-dimethyl-5-nitropyrimidin-4-amine

Chemical Property:

Vapor Pressure:3.76E-06mmHg at 25°C
Refractive Index:1.632
Boiling Point:385.6 °C at 760 mmHg
Flash Point:187 °C
Density:1.496 g/cm³
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:202.0257532
Heavy Atom Count:13
Complexity:198

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=NC(=N1)Cl)NC)[N+](=O)[O-]

Technology Process of 2-Chloro-n,6-dimethyl-5-nitropyrimidin-4-amine

There total 2 articles about 2-Chloro-n,6-dimethyl-5-nitropyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 13162-26-0
2,4-dichloro-6-methyl-5-nitropyrimidine

: 74-89-5
methylamine

: 5177-14-0
2-chloro-N,6-dimethyl-5-nitropyrimidin-4-amine

Guidance literature:: In tetrahydrofuran; water; at -40 ℃; for 4h;
DOI:10.1016/j.bmc.2017.12.025

Reference yield:

: 5177-14-0
2-chloro-N,6-dimethyl-5-nitropyrimidin-4-amine

Guidance literature:: 6-Methyl5-nitrouracil: 1) POCl3/PhNMe2 (2,4-Dichlorverb.) 2) MeNH2/MeOH/Et2O (12h 15grad);

Reference yield:

: 5177-14-0
2-chloro-N,6-dimethyl-5-nitropyrimidin-4-amine

: 2-amino-6-bromo-4,8-dimethylpteridin-7(8H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C

2: palladium on activated charcoal; hydrogen / methanol / 3 h / 20 °C

3: acetic acid / ethanol / 1 h / 100 °C

4: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C

With ammonium hydroxide; N-Bromosuccinimide; palladium on activated charcoal; hydrogen; acetic acid; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2017.12.025