N¹-(trifluoroacetyl)-N⁹-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine

Base Information

• Chemical Name: N¹-(trifluoroacetyl)-N⁹-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine
• CAS No.: 674297-96-2
• Molecular Formula: C₁₈H₂₈F₃N₃O₃
• Molecular Weight: 391.434
• Mol file: 674297-96-2.mol

Synonyms:N¹-(trifluoroacetyl)-N⁹-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine

Chemical Property of N¹-(trifluoroacetyl)-N⁹-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-(trifluoroacetyl)-N⁹-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine

There total 2 articles about N¹-(trifluoroacetyl)-N⁹-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-acetyldimedone (1755-15-3) + N-[3-(3-amino-propylamino)-propyl]-2,2,2-trifluoro-acetamide → N1-(trifluoroacetyl)-N9-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine (674297-96-2) + N1,N9-bis-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine (674297-98-4)

Guidance literature:

In dichloromethane; for 12h;

DOI:10.1002/chem.200305232

Reference yield:

bis(3-aminopropyl)amine (56-18-8) → N1-(trifluoroacetyl)-N9-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine (674297-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 4 h / 0 °C

2: 61 percent / CH₂Cl₂ / 12 h

In methanol; dichloromethane;

DOI:10.1002/chem.200305232

Reference yield: 88.0%

4-nitrophenyl-4'-hydroxymethylphenyl-1'-oxyallylacetate carbonate (192064-31-6) + N1-(trifluoroacetyl)-N9-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine (674297-96-2) → N1-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-N5-(4-(allyloxycarbonylmethoxy)phenyl-methoxycarbonyl)-(N9-trifluoroacetyl)-norspermidine (674298-00-1)

Guidance literature:

In N,N-dimethyl-formamide; for 12h;

DOI:10.1002/chem.200305232

upstream raw materials:

2-acetyldimedone

bis(3-aminopropyl)amine

Downstream raw materials:

N¹-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-N⁵-(4-(allyloxycarbonylmethoxy)phenyl-methoxycarbonyl)-(N⁹-trifluoroacetyl)-norspermidine

N¹-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-N⁵-(4-(carboxymethyl)phenyl-methoxycarbonyl)-(N⁹-trifluoroacetyl)-norspermidine