674297-98-4

Upstream product

• 1755-15-3 2-acetyldimedone 
• 56-18-8 bis(3-aminopropyl)amine 
• 94142-97-9 2-(1-hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione 

Downstream Products

• 674298-03-4 N¹,N⁹-bis-1,1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-N⁵-(3-carboxypropanoyl)-norspermidine 
• 862124-46-7 N¹,N⁹-bis[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-N⁵-[4-(allyloxycarbonylmethoxy)benzyloxycarbonyl]norspermidine 
• 1350564-35-0 N,N-bis(3-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)ethylamino]propyl)maleamic acid 
• 862124-47-8 N¹,N⁹-bis[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-N⁵-[4-(hydroxycarbonylmethoxy)benzyloxycarbonyl]norspermidine 

Relevant academic research and scientific papers

Cationic lipids

The invention provides a cationic lipid comprising: (i) one head group, comprising one or more amino acids, in which at least one amino acid has a side chain that comprises a cationic moiety or a cationic precursor;(ii) a linking moiety of formula (5): [i

Solid-phase synthesis of arginine-based double-tailed cationic lipopeptides: Potent nucleic acid carriers

Herein we report a highly-efficient solid-phase strategy for the modular synthesis of 63 double-tailed lipid-peptide conjugates and their application in DNA delivery.

Mechanism and structure-activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase

A library of polyamine-peptide conjugates based around some previously identified inhibitors of trypanothione reductase was synthesised by parallel solid-phase chemistry and screened. Kinetic analysis of library members established that subtle structural

Solid-Phase Synthesis of 89 Polyamine-Based Cationic Lipids for DNA Delivery to Mammalian Cells

The ability of non-viral gene delivery systems to overcome extracellular and intracellular barriers is a critical issue for future clinical applications of gene therapy. In recent years much effort has been focused on the development of a variety of DNA c