(Z)-4-hydroxy-N-methyl-3-(pyridin-4-yl)-2-(4-(quinolin-2-ylmethoxy)phenyl)but-2-enamide

Base Information

Chemical Name:(Z)-4-hydroxy-N-methyl-3-(pyridin-4-yl)-2-(4-(quinolin-2-ylmethoxy)phenyl)but-2-enamide
CAS No.:1202376-30-4
Molecular Formula:C₂₆H₂₃N₃O₃
Molecular Weight:425.487
Hs Code.:

Synonyms:(Z)-4-hydroxy-N-methyl-3-(pyridin-4-yl)-2-(4-(quinolin-2-ylmethoxy)phenyl)but-2-enamide

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Chemical Property of (Z)-4-hydroxy-N-methyl-3-(pyridin-4-yl)-2-(4-(quinolin-2-ylmethoxy)phenyl)but-2-enamide

Chemical Property:

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Technology Process of (Z)-4-hydroxy-N-methyl-3-(pyridin-4-yl)-2-(4-(quinolin-2-ylmethoxy)phenyl)but-2-enamide

There total 7 articles about (Z)-4-hydroxy-N-methyl-3-(pyridin-4-yl)-2-(4-(quinolin-2-ylmethoxy)phenyl)but-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1202376-29-1
4-(pyridin-4-yl)-3-(4-(quinolin-2-ylmethoxy)phenyl)furan-2(5H)-one

: 74-89-5
methylamine

: 1202376-30-4
(Z)-4-hydroxy-N-methyl-3-(pyridin-4-yl)-2-(4-(quinolin-2-ylmethoxy)phenyl)but-2-enamide

Guidance literature:: In methanol; for 1h; Reflux;

Reference yield:

: 4377-41-7
2-Chloromethylquinoline

: 1202376-30-4
(Z)-4-hydroxy-N-methyl-3-(pyridin-4-yl)-2-(4-(quinolin-2-ylmethoxy)phenyl)but-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 16 h / 80 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

3.1: triethylamine / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.2: 2 h / 0 °C

4.1: methanol / 1 h / Reflux

With water; potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 1122-54-9
methyl (4-pyridyl) ketone

: 1202376-30-4
(Z)-4-hydroxy-N-methyl-3-(pyridin-4-yl)-2-(4-(quinolin-2-ylmethoxy)phenyl)but-2-enamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine / tetrachloromethane / 1 h / Reflux

2.1: triethylamine / acetonitrile / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 0 °C

3.1: methanol / 1 h / Reflux

With bromine; triethylamine; In methanol; tetrachloromethane; acetonitrile;