2-(PIPERIDIN-4-YLOXY)PYRIDINE DIHYDROCHLORIDE

Base Information

• Chemical Name: 2-(PIPERIDIN-4-YLOXY)PYRIDINE DIHYDROCHLORIDE
• CAS No.: 313490-36-7
• Molecular Formula: C₁₀H₁₄N₂O*2ClH
• Molecular Weight: 251.156
• Hs Code.: 2933399990
• Mol file: 313490-36-7.mol

Synonyms:Pyridine,2-(4-piperidinyloxy)-, dihydrochloride (9CI); 2-(Piperidin-4-yloxy)pyridinedihydrochloride; 2-[(Piperidinium-4-yl)oxy]pyridinium dichloride;4-(2-Pyridyloxy)piperidine dihydrochloride

Chemical Property of 2-(PIPERIDIN-4-YLOXY)PYRIDINE DIHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 3.73E-05mmHg at 25°C
• Boiling Point: 347.7°C at 760 mmHg
• Flash Point: 164.1°C
• PSA: 34.15000
• LogP: 3.14520
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-[(Piperidin-4-yl)oxy]pyridine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(PIPERIDIN-4-YLOXY)PYRIDINE DIHYDROCHLORIDE

There total 6 articles about 2-(PIPERIDIN-4-YLOXY)PYRIDINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-(pyridin-2-yloxy)piperidine-1-carboxylate (313490-35-6) → 2-(piperidin-4-yloxy)pyridine dihydrochloride (1185308-16-0,313490-36-7)

Guidance literature:

With hydrogenchloride; methanol; water; at 20 ℃; for 0.5h;

Reference yield: 95.0%

tert-butyl 4-(pyridin-2-yloxy)piperidine-1-carboxylate (313490-35-6) → 2-(piperidin-4-yloxy)pyridine dihydrochloride (313490-36-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 23 ℃; for 3h;

Reference yield:

2-bromo-pyridine (109-04-6) → 2-(piperidin-4-yloxy)pyridine dihydrochloride (1185308-16-0,313490-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 0.17 h / 20 °C

1.2: 6 h / Heating / reflux

2.1: hydrogenchloride; methanol; water / 0.5 h / 20 °C

With hydrogenchloride; methanol; water; sodium hydride; In 1-methyl-pyrrolidin-2-one;

upstream raw materials:

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-(pyridin-2-yloxy)piperidine-1-carboxylate

2-hydroxypyridin

2-bromo-pyridine

Refernces

• 1、 -. "3-HETEROCYCLYL-4-PHENYL-TRIAZOLE DERIVATIVES AS INHIBITORS OF THE VASOPRESSIN V1A RECEPTOR". Page/Page column 38. . Retrieved 2010/02/14.