1-Boc-4-(2-pyridyloxy)piperidine

Base Information

• Chemical Name: 1-Boc-4-(2-pyridyloxy)piperidine
• CAS No.: 313490-35-6
• Molecular Formula: C₁₅H₂₂N₂O₃
• Molecular Weight: 278.351
• Hs Code.: 2933990090
• Mol file: 313490-35-6.mol

Synonyms:

Chemical Property of 1-Boc-4-(2-pyridyloxy)piperidine

Chemical Property:

• PSA: 51.66000
• LogP: 2.79780
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-Boc-4-(2-pyridyloxy)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Boc-4-(2-pyridyloxy)piperidine is used as a reactant in the preparation of pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors.

Technology Process of 1-Boc-4-(2-pyridyloxy)piperidine

There total 4 articles about 1-Boc-4-(2-pyridyloxy)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-bromo-pyridine (109-04-6) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-(pyridin-2-yloxy)piperidine-1-carboxylate (313490-35-6)

Guidance literature:

t-butyl 4-hydroxy piperidine-1-carboxylate; With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.166667h;

2-bromo-pyridine; In 1-methyl-pyrrolidin-2-one; for 6h; Heating / reflux;

Reference yield: 41.0%

2-hydroxypyridin (142-08-5) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-(pyridin-2-yloxy)piperidine-1-carboxylate (313490-35-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 23 ℃; for 5h; Inert atmosphere;

Reference yield:

2-chloropyridine (109-09-1) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-(pyridin-2-yloxy)piperidine-1-carboxylate (313490-35-6)

Guidance literature:

With 18-crown-6 ether; In toluene; for 18h; Heating / reflux;

upstream raw materials:

2-bromo-pyridine

t-butyl 4-hydroxy piperidine-1-carboxylate

2-chloropyridine

2-hydroxypyridin

Downstream raw materials:

2-(piperidin-4-yloxy)pyridine dihydrochloride

N-(4-chlorophenyl)-4-(pyridin-2-yloxy)piperidine-1-carbothioamide

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide

2-(piperidin-4-yloxy)pyridine

Refernces

• 1、 -. "PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS". Paragraph 2271; 2272. . Retrieved 2016/08/03.
• 2、 -. "3-HETEROCYCLYL-4-PHENYL-TRIAZOLE DERIVATIVES AS INHIBITORS OF THE VASOPRESSIN V1A RECEPTOR". Page/Page column 38. . Retrieved 2010/02/14.