14588-60-4

Basic information

• Product Name: 3,5-dimethoxy-4-phenylmethoxy-benzoate
• Synonyms: 3,5-dimethoxy-4-phenylmethoxy-benzoate;3,5-dimethoxy-4-(phenylmethoxy)Benzoic acid
• CAS NO: 14588-60-4
• Molecular Formula: C₁₆H₁₆O₅
• Molecular Weight: 288.3
• Mol File: 14588-60-4.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 440.8°Cat760mmHg
• Flash Point: 161.5°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.51E-08mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,5-dimethoxy-4-phenylmethoxy-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dimethoxy-4-phenylmethoxy-benzoate(14588-60-4)
• EPA Substance Registry System: 3,5-dimethoxy-4-phenylmethoxy-benzoate(14588-60-4)

Safety Data

• Hazardous Substances Data: 14588-60-4(Hazardous Substances Data)

Usage

General Description

3,5-dimethoxy-4-phenylmethoxy-benzoate is a chemical compound with the molecular formula C17H18O5. It is a benzene derivative with two methoxy groups and a phenylmethoxy group attached to the benzoate core. 3,5-dimethoxy-4-phenylmethoxy-benzoate is often used in research and drug development due to its potential pharmacological properties. Its structure suggests that it may have biological activity, and it is currently being investigated for its potential as a therapeutic agent. The compound may also have uses in the fields of organic chemistry and material science, as its structure makes it a potentially valuable building block for the synthesis of other complex molecules.

InChI:InChI=1/C16H16O5/c1-19-13-8-12(16(17)18)9-14(20-2)15(13)21-10-11-6-4-3-5-7-11/h3-9H,10H2,1-2H3,(H,17,18)

Upstream product

• 118-41-2 Eudesmic acid 
• 884-35-5 methyl syringate 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 1916-07-0 3,4,5-trimethoxybenzoic acid methyl ester 
• 530-57-4 3,5-dimethoxy-4-hydroxybenzoic acid 
• 99463-10-2 benzyl 4-(benzyloxy)-3,5-dimethoxybenzoate 
• 27065-65-2 methyl 4-benzyloxy-3,5-dimethoxybenzoate 

Downstream Products

• 530-57-4 3,5-dimethoxy-4-hydroxybenzoic acid 
• 302968-98-5 (4-benzyloxy-3,5-dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-pyrrolidin-1-yl]-methanone 
• 1195777-18-4 4-benzyloxy-3,5-dimethoxybenzoic acid 5-chloro-2-butyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl methyl ester 
• 1166820-78-5 3-O-(4-hydroxy-3,5-dimethoxybenzoyl)catechin 
• 1166820-76-3 5,7,3',4'4''-penta-O-acetyl-3-O-(3,5-dimethoxybenzoyl)catechin 

Relevant articles and documents

Synthesis and evaluation of new sesamol-based phenolic acid derivatives with hypolipidemic, antioxidant, and hepatoprotective effects

The objective of this study is to synthesize a series of sesamol-based phenolic acid derivatives, which were designed by combination principle. The hypolipidemic activity of all these compounds was preliminarily screened by acute hyperlipidemic mice model induced by Triton WR 1339, in which compound T6 exhibited more significant reducing plasma TG and TC than fenofibrate. Compound T6 was also found to obviously decrease TG and TC both in the plasma and hepatic tissue of high-fat-diet-induced hyperlipidemic mice. Moreover, T6 showed hepatoprotective effects, which remarkable amelioration in characteristic liver enzymes was examined and the histopathological observation displayed that compound T6 inhibited lipids accumulation in the hepatic. The levels of PPAR-α receptor related to lipids metabolism in hepatic tissue were upregulated after T6 treatment. Other potent effects of T6 such as antioxidant and anti-inflammatory activity were also observed. On the bases of these findings, compound T6 may serve as an effective hypolipidemic and hepatoprotective agent. [Figure not available: see fulltext.]

Herba Leonuri (motherwort) alkali analogs and method for preparation thereof

The invention belongs to the field of medicinal chemistry and in particular relates to a leonurine analog and a preparation method thereof. The leonurine analog provided by the invention has a structure of a formula (1). The preparation method comprises the following steps of: combining a Chinese medicinal monomer with an active gas molecule by using a computer simulation aided design, wherein leonurine serves as a lead compound; and introducing a signal molecule hydrogen sulphide releasing group to a guanidyl of the leonurine, so that controllable release can be realized in vivo and unique double protective action of the traditional Chinese medicinal monomer and the active gas molecule can be exerted. A primary test shows that the prepared leonurine has protective action on myocardial ischemia in vitro and in vivo and can be further used for preparing a medicament for treating heart cerebrovascular diseases. In the formula, m is 1 to 6 and n is 2 to 3.

NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF

Disclosed are a novel benzamide derivative and pharmaceutical use thereof, and more particularly, a novel benzamide derivative having a structure of Formula 1 or pharmaceutically acceptable salts thereof, and a composition for prevention or treatment of pain or itching including the above material. The novel benzamide derivative and pharmaceutically acceptable salt thereof according to the present invention exhibit excellent pain-suppressive effect and, in particular, pain-suppressive effect in not only a neuropathic animal model but also other models such as a formalin model, and therefore, may be used in suppression of different pains such as nociceptive pain, chronic pain, etc. Further, since it was demonstrated that the present invention displays anti-pruritic efficacy even in an itching model, to which a mechanism and treatment concept established with respect to pain is applied, the present invention may also be effectively used in radical treatment of atopic dermatitis by applying the inventive product to an anti-pruritic composition in order to suppress an initial itching stage and treat symptoms thereof, thus preventing skin damage or inflammation after the scratching stage.