dimethyl 2-[(4-ethynylphenyl)ethynyl]-2',4'a-dimethylspiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

Base Information

Chemical Name:dimethyl 2-[(4-ethynylphenyl)ethynyl]-2',4'a-dimethylspiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate
CAS No.:1239233-48-7
Molecular Formula:C₃₅H₂₆N₂O₄
Molecular Weight:538.602
Hs Code.:

Synonyms:dimethyl 2-[(4-ethynylphenyl)ethynyl]-2',4'a-dimethylspiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

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Chemical Property of dimethyl 2-[(4-ethynylphenyl)ethynyl]-2',4'a-dimethylspiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

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Technology Process of dimethyl 2-[(4-ethynylphenyl)ethynyl]-2',4'a-dimethylspiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

There total 9 articles about dimethyl 2-[(4-ethynylphenyl)ethynyl]-2',4'a-dimethylspiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1239233-54-5
dimethyl 2',4'a-dimethyl-2-[[4-[(trimethylsilyl)ethynyl]phenyl]ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

: 1239233-48-7
dimethyl 2-[(4-ethynylphenyl)ethynyl]-2',4'a-dimethylspiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1007/s00706-010-0267-7

Reference yield: 24.0%

: 1632-74-2
3,6-dimethylpyridazine

: 1239233-42-1
C₂₉H₁₈O₄

: 1239233-48-7
dimethyl 2-[(4-ethynylphenyl)ethynyl]-2',4'a-dimethylspiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

Guidance literature:: In diethyl ether; at 20 ℃; Inert atmosphere; Darkness;
DOI:10.1007/s00706-010-0267-7

Reference yield:

: 66228-76-0
4-(trimethylsilylethynyl)phenylacetylene

: 1239233-48-7
dimethyl 2-[(4-ethynylphenyl)ethynyl]-2',4'a-dimethylspiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / tetrahydrofuran / 4 h

2: hydrazine hydrate / ethanol / 3 h / Reflux

3: manganese(IV) oxide / diethyl ether / 20 °C / Darkness

4: diethyl ether / 8 h / Darkness

5: diethyl ether / 2 h / Inert atmosphere; Photolysis

6: diethyl ether / 20 °C / Inert atmosphere; Darkness

With manganese(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrazine hydrate; diethylamine; In tetrahydrofuran; diethyl ether; ethanol; 1: Sonogashira coupling;
DOI:10.1007/s00706-010-0267-7