3,6-Dimethyl Pyridazine

Base Information

• Chemical Name: 3,6-Dimethyl Pyridazine
• CAS No.: 1632-74-2
• Molecular Formula: C6H8N2
• Molecular Weight: 108.143
• Hs Code.: 2933990090
• Mol file: 1632-74-2.mol

Synonyms:3,6-Dimethylpyridazin;Dimethylpyridazin;Pyridazine,3,6-dimethyl;QC-5805;3,6-dimethyl-pyridazine;

Chemical Property of 3,6-Dimethyl Pyridazine

Chemical Property:

• Melting Point: 32-33℃
• Boiling Point: 228.2 °C at 760 mmHg
• PKA: 4.04±0.10(Predicted)
• Flash Point: 100.4 °C
• PSA: 25.78000
• Density: 0.997 g/cm³
• LogP: 1.09340
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3,6-Dimethylpyridazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,6-Dimethyl Pyridazine

There total 19 articles about 3,6-Dimethyl Pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C9H13N3O2 (76473-32-0) → 3,6-dimethylpyridazine (1632-74-2) + 2,5-dimethyl-pyrrole-1-carboxylic acid ethyl ester (76473-34-2)

Guidance literature:

In benzene; for 22h; Irradiation;

DOI:10.1248/cpb.28.2676

Reference yield: 56.0%

2,5-hexanedione (110-13-4) → 3,6-dimethylpyridazine (1632-74-2)

Guidance literature:

2,5-hexanedione; With hydrazine hydrate; In ethanol; for 3h; Reflux;

With palladium 10% on activated carbon; In ethanol; benzene; Reflux;

Reference yield: 40.0%

3-hexyn-2,5-diol (3031-66-1) → 3,6-dimethylpyridazine (1632-74-2)

Guidance literature:

3-hexyn-2,5-diol; With carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; for 3h; Inert atmosphere; Reflux;

With hydrazine hydrate; In toluene; for 17h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2009.06.108

upstream raw materials:

4-chloro-3,6-dimethylpyridazine

2,5-dimethoxy-2,5-dimethyl-2,5-dihydro-furan

3,6-dimethyl-2,3,4,5-tetrahydro-pyridazine-3-carbonitrile

3-hydroxyhexane-2,5-dione

Downstream raw materials:

2,4,6-Trimethyl-benzenesulfonate1-amino-3,6-dimethyl-pyridazin-1-ium;

dimethyl 2,7-bis((4-ethynylphenyl)ethynyl)-2',4a'-dimethyl-4a'H-spiro[fluorene-9,5'-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

C₁₈H₁₅F₃N₂O₂

pyridazine-3,6-dicarboxylic acid

Refernces

• 1、 -. "Compounds for treating spinal muscular atrophy". Page/Page column 395; 396. . Retrieved 2017/05/02.
• 2、 Pridmore, Simon J.,Slatford, Paul A.,Taylor, James E.,Whittlesey, Michael K.,Williams, Jonathan M.J.. "Synthesis of furans, pyrroles and pyridazines by a ruthenium-catalysed isomerisation of alkynediols and in situ cyclisation". supporting information; experimental part. p. 8981 - 8986. Retrieved 2009/12/27.