1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-one

Base Information

Chemical Name:1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-one
CAS No.:186826-80-2
Molecular Formula:C₃₅H₃₇ClN₂O₂
Molecular Weight:553.144
Hs Code.:

Synonyms:1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-one

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Chemical Property of 1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-one

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Technology Process of 1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-one

There total 7 articles about 1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186826-78-8
1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-ol

: 186826-80-2
1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-one

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 40 - 50 ℃; for 168h;
DOI:10.1021/jm960320m

Reference yield:

: 1458-63-5
N-(3-chloropropyl)-piperidine

: 186826-80-2
1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Mg, ethyl bromide, I₂ / 1.) THF, reflux, 30 min, 2.) THF, 60 deg C, 24 h

2: 1.6 g / MnO₂ / CH₂Cl₂ / 168 h / 40 - 50 °C

With manganese(IV) oxide; ethyl bromide; iodine; magnesium; In dichloromethane;
DOI:10.1021/jm960320m

Reference yield:

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 186826-80-2
1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / pyridine / CH₂Cl₂ / Ambient temperature

2: 59 percent / LiAlH₄ / tetrahydrofuran / 4 h / Ambient temperature

3: 86 percent / MnO₂ / CH₂Cl₂ / 24 h / Ambient temperature

4: 1.) Mg, ethyl bromide, I₂ / 1.) THF, reflux, 30 min, 2.) THF, 60 deg C, 24 h

5: 1.6 g / MnO₂ / CH₂Cl₂ / 168 h / 40 - 50 °C

With pyridine; manganese(IV) oxide; lithium aluminium tetrahydride; ethyl bromide; iodine; magnesium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm960320m