1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-ol

Base Information

Chemical Name:1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-ol
CAS No.:186826-78-8
Molecular Formula:C₃₅H₃₉ClN₂O₂
Molecular Weight:555.16
Hs Code.:

Synonyms:1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-ol

Suppliers and Price of 1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-ol

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Chemical Property of 1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-ol

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Technology Process of 1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-ol

There total 5 articles about 1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 186826-78-8
1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / pyridine / CH₂Cl₂ / Ambient temperature

2: 59 percent / LiAlH₄ / tetrahydrofuran / 4 h / Ambient temperature

3: 86 percent / MnO₂ / CH₂Cl₂ / 24 h / Ambient temperature

4: 1.) Mg, ethyl bromide, I₂ / 1.) THF, reflux, 30 min, 2.) THF, 60 deg C, 24 h

With pyridine; manganese(IV) oxide; lithium aluminium tetrahydride; ethyl bromide; iodine; magnesium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm960320m

Reference yield:

: 76-83-5
trityl chloride

: 186826-78-8
1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / pyridine / CH₂Cl₂ / Ambient temperature

2: 59 percent / LiAlH₄ / tetrahydrofuran / 4 h / Ambient temperature

3: 86 percent / MnO₂ / CH₂Cl₂ / 24 h / Ambient temperature

4: 1.) Mg, ethyl bromide, I₂ / 1.) THF, reflux, 30 min, 2.) THF, 60 deg C, 24 h

With pyridine; manganese(IV) oxide; lithium aluminium tetrahydride; ethyl bromide; iodine; magnesium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm960320m

Reference yield:

: 186826-77-7
[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-methanol

: 186826-78-8
1-[5-Chloro-2-methoxy-4-(trityl-amino)-phenyl]-4-piperidin-1-yl-butan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / MnO₂ / CH₂Cl₂ / 24 h / Ambient temperature

2: 1.) Mg, ethyl bromide, I₂ / 1.) THF, reflux, 30 min, 2.) THF, 60 deg C, 24 h

With manganese(IV) oxide; ethyl bromide; iodine; magnesium; In dichloromethane;
DOI:10.1021/jm960320m