10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester

Base Information

Chemical Name:10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester
CAS No.:862097-47-0
Molecular Formula:C₄₀H₆₆N₆O₁₁
Molecular Weight:806.998
Hs Code.:

10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester

Synonyms:10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester

Suppliers and Price of 10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester

There total 3 articles about 10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 126849-87-4
(3-benzyloxycarbonylaminoaminopropylamino)acetic acid ethyl ester

: 247193-74-4
2-(4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetic acid

: 862097-47-0
10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester

Guidance literature:: 2-(4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In acetonitrile; for 0.5h;

(3-benzyloxycarbonylaminoaminopropylamino)acetic acid ethyl ester; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/ja052191h

Reference yield:

: 46460-73-5
N-benzyloxycarbonyl-1,3-diaminopropane

: 862097-47-0
10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 7.6 g / TEA / CH₂Cl₂ / 12 h / 20 °C

2.1: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium*PF₆ / acetonitrile / 0.5 h

2.2: 69 percent / DIEA / acetonitrile / 1 h / 20 °C

With TEA; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In dichloromethane; acetonitrile;
DOI:10.1021/ja052191h

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 862097-47-0
10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / CH₂Cl₂ / 3 h

2.1: 7.6 g / TEA / CH₂Cl₂ / 12 h / 20 °C

3.1: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium*PF₆ / acetonitrile / 0.5 h

3.2: 69 percent / DIEA / acetonitrile / 1 h / 20 °C

With TEA; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/ja052191h