3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid

Base Information

Chemical Name:3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid
CAS No.:103253-35-6
Molecular Formula:C₂₂H₂₄ClNO₃
Molecular Weight:385.89
Hs Code.:

Synonyms:3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid

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Chemical Property of 3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid

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Technology Process of 3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid

There total 4 articles about 3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 15118-53-3
2,2-dimethyl-4-oxohexanoic acid

: 20955-94-6
1-[(4-chlorophenyl)methyl]-1-(4-methoxyphenyl)-hydrazine hydrochloride

: 103253-35-6
3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid

Guidance literature:: In tert-butyl alcohol; for 15h; Heating;
DOI:10.1016/j.bmcl.2005.05.027

Reference yield:

: 15118-75-9
methyl 2,2-dimethyl-4-oxohexanoate

: 20955-94-6
1-[(4-chlorophenyl)methyl]-1-(4-methoxyphenyl)-hydrazine hydrochloride

: 103253-35-6
3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid

Guidance literature:

Reference yield:

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 103253-35-6
3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / Et₃N / toluene / 15 h / Heating

2: 54 percent / 2-methyl-propan-2-ol / 15 h / Heating

With triethylamine; In toluene; tert-butyl alcohol; 2: Fisher indole coupling;
DOI:10.1016/j.bmcl.2005.05.027